Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Human brain functional network changes associated with enhanced and impaired attentional task performance.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The hubs of the human connectome are generally implicated in the anatomy of brain disorders.Brain : a journal of neurology · 2014Pooled it
- Modular reconfiguration of an auditory control brain network supports adaptive listening behavior.Proceedings of the National Academy of Sciences of the United States of America · 2019Trial
- Nicotine normalizes cortico-striatal connectivity in non-smoking individuals with major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Effects of nicotine on response inhibition and interference control.Psychopharmacology · 2017Trial
- Elevating understanding: Linking high-altitude hypoxia to brain aging through EEG functional connectivity and spectral analyses.Network neuroscience (Cambridge, Mass.) · 2024Article
- Modulation of High-Frequency rTMS on Reward Circuitry in Individuals with Nicotine Dependence: A Preliminary fMRI Study.Neural plasticity · 2024Article
- Cognitive Alterations in Addictive Disorders: A Translational Approach.Biomedicines · 2023Review
- Article
- Differences in functional brain organization during gesture recognition between autistic and neurotypical individuals.Social cognitive and affective neuroscience · 2022Article
- Directed Brain Network Analysis for Fatigue Driving Based on EEG Source Signals.Entropy (Basel, Switzerland) · 2022Article
- Article
- Functional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder.Scientific reports · 2021Article
- Cholinergic neuromodulation of inhibitory interneurons facilitates functional integration in whole-brain models.PLoS computational biology · 2021Article
- Bayesian Joint Modeling of Multiple Brain Functional Networks.Journal of the American Statistical Association · 2021Article
- Altered Structural and Functional MRI Connectivity in Type 2 Diabetes Mellitus Related Cognitive Impairment: A Review.Frontiers in human neuroscience · 2021Review
- Individual differences in local functional brain connectivity affect TMS effects on behavior.Scientific reports · 2020Article
- Weighted network measures reveal differences between dementia types: An EEG study.Human brain mapping · 2020Article
- Cognitive performance effects of nicotine and industry affiliation: a systematic review.Substance abuse : research and treatment · 2020Article
- Making Sense of Connectivity.The international journal of neuropsychopharmacology · 2019Review
- Healthy Subjects With Extreme Patterns of Performance Differ in Functional Network Topology and Benefits From Nicotine.Frontiers in systems neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
How is the cognitive performance of the human brain related to its topological and spatial organization as a complex network embedded in anatomical space? To address this question, we used nicotine replacement and duration of attentionally demanding task performance (time-on-task), as experimental factors expected, respectively, to enhance and impair cognitive function. We measured resting-state fMRI data, performance and brain activation on a go/no-go task demanding sustained attention, and subjective fatigue in n = 18 healthy, briefly abstinent, cigarette smokers scanned repeatedly in a placebo-controlled, crossover design. We tested the main effects of drug (placebo vs Nicorette gum) and time-on-task on behavioral performance and brain functional network metrics measured in binary graphs of 477 regional nodes (efficiency, measure of integrative topology; clustering, a measure of segregated topology; and the Euclidean physical distance between connected nodes, a proxy marker of wiring cost). Nicotine enhanced attentional task performance behaviorally and increased efficiency, decreased clustering, and increased connection distance of brain networks. Greater behavioral benefits of nicotine were correlated with stronger drug effects on integrative and distributed network configuration and with greater frequency of cigarette smoking. Greater time-on-task had opposite effects: it impaired attentional accuracy, decreased efficiency, increased clustering, and decreased connection distance of networks. These results are consistent with hypothetical predictions that superior cognitive performance should be supported by more efficient, integrated (high capacity) brain network topology at greater connection distance (high cost). They also demonstrate that brain network analysis can provide novel and theoretically principled pharmacodynamic biomarkers of pro-cognitive drug effects in humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.