ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- What Do We Know About the Influence of the Cerebellum on Walking Ability? Promising Findings from Transcranial Alternating Current Stimulation.Cerebellum (London, England) · 2017Trial
- Cerebellar Non-Invasive Brain Stimulation: A Frontier in Chronic Pain Therapy.Journal of personalized medicine · 2024Review
- Review
- Large conductance voltage-and calcium-activated KFrontiers in pharmacology · 2024Review
- The Cerebellar Cortex.Annual review of neuroscience · 2022Review
- Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex.Current research in neurobiology · 2022Article
- Physiology of Cerebellar Reserve: Redundancy and Plasticity of a Modular Machine.International journal of molecular sciences · 2021Review
- Calcium Channel-Dependent Induction of Long-Term Synaptic Plasticity at Excitatory Golgi Cell Synapses of Cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Acetylcholine Modulates Cerebellar Granule Cell Spiking by Regulating the Balance of Synaptic Excitation and Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Consensus Paper: Experimental Neurostimulation of the Cerebellum.Cerebellum (London, England) · 2019Review
- Diverse Neuron Properties and Complex Network Dynamics in the Cerebellar Cortical Inhibitory Circuit.Frontiers in molecular neuroscience · 2019Article
- Serotonin regulates dynamics of cerebellar granule cell activity by modulating tonic inhibition.Journal of neurophysiology · 2019Article
- Cerebellar Cortex as a Therapeutic Target for Neurostimulation.Cerebellum (London, England) · 2018Review
- Article
- Cerebellar Transcranial Direct Current Stimulation (ctDCS): A Novel Approach to Understanding Cerebellar Function in Health and Disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2016Review
- Inverse Relationship between Basal Pacemaker Neuron Activity and Aversive Long-Term Memory Formation inFrontiers in cellular neuroscience · 2016Article
- Cerebellar transcranial direct current stimulation in neurological disease.Cerebellum & ataxias · 2016Review
- Differential Regulation of Action Potential Shape and Burst-Frequency Firing by BK and Kv2 Channels in Substantia Nigra Dopaminergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Active Dendrites and Differential Distribution of Calcium Channels Enable Functional Compartmentalization of Golgi Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Golgi cells (GoCs) are inhibitory interneurons that influence the cerebellar cortical response to sensory input by regulating the excitability of the granule cell layer. While GoC inhibition is essential for normal motor coordination, little is known about the circuit dynamics that govern the activity of these cells. In particular, although GoC spontaneous spiking influences the extent of inhibition and gain throughout the granule cell layer, it is not known whether this spontaneous activity can be modulated in a long-term manner. Here we describe a form of long-term plasticity that regulates the spontaneous firing rate of GoCs in the rat cerebellar cortex. We find that membrane hyperpolarization, either by mGluR2 activation of potassium channels, or by somatic current injection, induces a long-lasting increase in GoC spontaneous firing. This spike rate plasticity appears to result from a strong reduction in the spike after hyperpolarization. Pharmacological manipulations suggest the involvement of calcium-calmodulin-dependent kinase II and calcium-activated potassium channels in mediating these firing rate increases. As a consequence of this plasticity, GoC spontaneous spiking is selectively enhanced, but the gain of evoked spiking is unaffected. Hence, this plasticity is well suited for selectively regulating the tonic output of GoCs rather than their sensory-evoked responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.