ReviewClinical microbiology reviews2013
Microbiology and treatment of acute apical abscesses.
Review in Clinical microbiology reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 2 syntheses or guidelines pooled it, 276 citations in OpenAlex.
- Association between endodontic symptoms and root canal microbiota: a systematic review and meta-analysis of bacteroidetes, spirochaetes and fusobacteriales.Clinical oral investigations · 2024Pooled it
- Prevalence of unculturable bacteria in the periapical abscess: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Comparison between isolated and associated with codeine acetaminophen in pain control of acute apical abscess: a randomized clinical trial.Clinical oral investigations · 2021Trial
- Trial
- Comparison of two combinations of opioid and non-opioid analgesics for acute periradicular abscess: a randomized clinical trial.Journal of applied oral science : revista FOBTrial
- Procalcitonin as a predictor of length of stay in patients with odontogenic infections.Oral and maxillofacial surgery · 2026Article
- From Caries to Periodontal Breakdown: A Biological and Clinical Continuum Linking Cariology, Operative Dentistry, Endodontics, and Periodontology.Dentistry journal · 2026Review
- Bioactive peptides in Endodontic infections: The Good, The Bad, and The Ugly.Probiotics and antimicrobial proteins · 2026Review
- Paired oral clinical specimens reveal the underlying ecology supporting the emergence of inflammophilic microbiome communities.bioRxiv : the preprint server for biology · 2026Article
- IntratumoralScience advances · 2026Article
- Assessing the Efficacy of Antibiotic Therapy: A Retrospective Study Comparing 875 mg vs. 500 mg of Amoxicillin/Clavulanic Acid for the Management of Acute Apical Abscesses.Dentistry journal · 2026Article
- Host Immunogenetic Profile Modulates Susceptibility to Apical Periodontitis in a Colombian Population.Current issues in molecular biology · 2026Article
- Investigation of antibiotic release from amoxicillin- and clindamycin-impregnated silk and Vicryl suture materials: an in vitro study.BMC oral health · 2026Article
- Two-Year Outcomes of Regenerative Therapy in an Immature Maxillary Molar With Periapical Abscess: A Case Report.Case reports in dentistry · 2026Article
- Operative stewardship: reclaiming the role of surgical source control in dental antimicrobial stewardship.Frontiers in oral health · 2026Article
- Acute Exacerbation of Chronic Periapical Pathology in a Dentist: An Autobiographical Case Report.Cureus · 2026Article
- Endodontic management of maxillary premolars with three roots: a case series.Frontiers in oral health · 2026Article
- Reactive oxygen species-sensitive release of cephalexin from hyaluronic acid-g-cephalexin dimer copolymer for treatment of inflammation and infection of oral soft tissue cells.Scientific reports · 2025Article
- Navigating the Treatment Landscape of Odontogenic Sinusitis: Current Trends and Future Directions.Medicina (Kaunas, Lithuania) · 2025Review
- Complete genome sequence ofMicrobiology resource announcements · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute apical abscess is the most common form of dental abscess and is caused by infection of the root canal of the tooth. It is usually localized intraorally, but in some cases the apical abscess may spread and result in severe complications or even mortality. The reasons why dental root canal infections can become symptomatic and evolve to severe spreading and sometimes life-threatening abscesses remain elusive. Studies using culture and advanced molecular microbiology methods for microbial identification in apical abscesses have demonstrated a multispecies community conspicuously dominated by anaerobic bacteria. Species/phylotypes commonly found in these infections belong to the genera Fusobacterium, Parvimonas, Prevotella, Porphyromonas, Dialister, Streptococcus, and Treponema. Advances in DNA sequencing technologies and computational biology have substantially enhanced the knowledge of the microbiota associated with acute apical abscesses and shed some light on the etiopathogeny of this disease. Species richness and abundance and the resulting network of interactions among community members may affect the collective pathogenicity and contribute to the development of acute infections. Disease modifiers, including transient or permanent host-related factors, may also influence the development and severity of acute abscesses. This review focuses on the current evidence about the etiology and treatment of acute apical abscesses and how the process is influenced by host-related factors and proposes future directions in research, diagnosis, and therapeutic approaches to deal with this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.