Evidence map›Paper›PMID 23554299›Full record

ReviewWiley interdisciplinary reviews. Systems biology and medicine

Branched-chain amino acid supplementation: impact on signaling and relevance to critical illness.

John S A Mattick, Kubra Kamisoglu, Marianthi G Ierapetritou, Ioannis P Androulakis, Francois Berthiaume

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Smokers with COPD Show a Shift in Energy and Nitrogen Metabolism at Rest and During Exercise.International journal of chronic obstructive pulmonary disease · 2020
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

John S A Mattick *Department of Chemical and Biochemical Engineering, Rutgers, the State University of New Jersey, Piscataway, New Jersey.
Kubra Kamisoglu *Department of Chemical and Biochemical Engineering, Rutgers, the State University of New Jersey, Piscataway, New Jersey.
Marianthi G IerapetritouDepartment of Chemical and Biochemical Engineering, Rutgers, the State University of New Jersey, Piscataway, New Jersey.
Ioannis P AndroulakisDepartment of Chemical and Biochemical Engineering, Rutgers, the State University of New Jersey, Piscataway, New Jersey.
Francois BerthiaumeDepartment of Biomedical Engineering, Rutgers, the State University of New Jersey, Piscataway, New Jersey.
Rutgers, The State University of New Jersey · US

Funding

Bioinformatics Analysis of Control Mechanisms of HypermetabolismR01GM082974 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI ANDROULAKIS, IOANNIS P · 2008 to 2011
$1.6M
NIGMS NIH HHS GM082974NIGMS NIH HHS R01 GM082974
6 · The paper itself

Abstract

The changes that occur in mammalian systems following trauma and sepsis, termed systemic inflammatory response syndrome, elicit major changes in carbohydrate, protein, and energy metabolism. When these events persist for too long they result in a severe depletion of lean body mass, multiple organ dysfunction, and eventually death. Nutritional supplementation has been investigated to offset the severe loss of protein, and recent evidence suggests that diets enriched in branched-chain amino acids (BCAAs) may be especially beneficial. BCAAs are metabolized in two major steps that are differentially expressed in muscle and liver. In muscle, BCAAs are reversibly transaminated to the corresponding α-keto acids. For the complete degradation of BCAAs, the α-keto acids must travel to the liver to undergo oxidation. The liver, in contrast to muscle, does not significantly express the branched-chain aminotransferase. Thus, BCAA degradation is under the joint control of both liver and muscle. Recent evidence suggests that in liver, BCAAs may perform signaling functions, more specifically via activation of mTOR (mammalian target of rapamycin) signaling pathway, influencing a wide variety of metabolic and synthetic functions, including protein translation, insulin signaling, and oxidative stress following severe injury and infection. However, understanding of the system-wide effects of BCAAs that integrate both metabolic and signaling aspects is currently lacking. Further investigation in this respect will help rationalize the design and optimization of nutritional supplements containing BCAAs for critically ill patients.

Indexed as

Amino Acids, Branched-ChainCritical IllnessDietary SupplementsHumansInsulinLiverMuscle, SkeletalReactive Oxygen SpeciesSignal TransductionTOR Serine-Threonine KinasesAmino Acids, Branched-ChainInsulinReactive Oxygen SpeciesTOR Serine-Threonine Kinases

Identifiers

PMID23554299
PMCPMC4482218
OpenAlexW2095194980

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.