ArticleJournal of clinical microbiology2013
Microbiological diagnosis of severe diarrhea in kidney transplant recipients by use of multiplex PCR assays.
Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Pooled it
- Severe Undernutrition Predicts Adverse Outcomes in Transplant Norovirus Infection.Kidney international reports · 2026Article
- Demographic characteristics and associated conditions in enteropathogenic Escherichia coli positive patients.Gut pathogens · 2026Article
- Diagnostical Performances of the FilmArray Gastro-Intestinal Panel in Kidney Transplant Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Infectious Diarrhea in Kidney Transplant Recipients.Cureus · 2025Article
- A Systematic Literature Review to Determine Gaps in Diagnosing Suspected Infection in Solid Organ Transplant Recipients.Open forum infectious diseases · 2025Article
- Enteric Pathogen Detection Using Multiplex PCR Assay in Kidney Transplant Recipients with Diarrhea-Retrospective Before-After Study.Infectious diseases and therapy · 2024Article
- Diagnostic performance of a multiplexed gastrointestinal PCR panel for identifying diarrheal pathogens in children undergoing hematopoietic stem cell transplant.World journal of pediatrics : WJP · 2024Article
- Evaluation of non-invasive diagnostic tools for diarrhea: a systematic review of point-of-care tests and biomarkers.Annals of medicine and surgery (2012) · 2024Review
- Reduced infant rhesus macaque growth rates due to environmental enteric dysfunction and association with histopathology in the large intestine.Nature communications · 2022Article
- Differences by transplant type in stool multiplex PCR testing for acute diarrhea in post-solid organ transplantation.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Article
- Epidemiology and outcomes of medically attended and microbiologically confirmed bacterial foodborne infections in solid organ transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Clinical characteristics, risk factors and outcome of severe Norovirus infection in kidney transplant patients: a case-control study.BMC infectious diseases · 2021Article
- Diarrhea in kidney transplant recipients: Etiology and outcome.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Observational
- Correlation between changes in gut flora and serum inflammatory factors in children with noninfectious diarrhea.The Journal of international medical research · 2020Article
- RecurringIDCases · 2020Article
- A Case of Intestinal Microsporidiosis in a Renal Transplant Recipient.Journal of medical cases · 2019Article
- Rationale of using multiplex polymerase chain reaction (PCR) panels for etiological diagnosis of infective diarrhea in the tropics.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2018Article
- Gastrointestinal pathogens in anti-FH antibody positive and negative Hemolytic Uremic Syndrome.Pediatric research · 2018Article
- Practical Guidance for Clinical Microbiology Laboratories: Laboratory Diagnosis of Parasites from the Gastrointestinal TractClinical microbiology reviews · 2018Review
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diarrhea is a frequent complication after kidney transplantation, ascribed to adverse effects of the immunosuppressive therapy in case of negative microbiological examination of the stools. The aim of this study was to improve the microbiological diagnosis by implementing molecular tests. Fifty-four severe diarrhea events that occurred in 49 adult kidney transplant recipients from September 2010 to November 2011 were investigated. One or several enteric pathogens were detected in 13 (23%) stool samples using classical microbiological methods versus 39 (72%) for the seven commercially available multiplex PCR assays used retrospectively (P = 0.006). Interestingly, molecular diagnosis identified 15 multiple infections compared to none using classical techniques. The primary pathogens detected were enteropathogenic Escherichia coli (EPEC) (n = 15; 38%), Campylobacter spp. (n = 15; 38%), and Norovirus (n = 14; 36%). Specificities for Campylobacter and Norovirus infection diagnosis were 75 and 100%, respectively, by comparison to reference methods. Based on molecular findings, a cyclosporine-mycophenolate mofetil combination was identified as a risk factor for developing Norovirus-induced diarrhea. Norovirus infections were also responsible for higher weight loss than all the other causes of diarrhea. In samples from asymptomatic immunocompromised and immunocompetent patients, EPEC but not Norovirus and Campylobacter infections were detected at a frequency similar to that observed in symptomatic kidney transplant recipients. In conclusion, molecular tools significantly improved the detection of single and multiple enteric infections by comparison to classical techniques and could quickly become the key element in the management of severe acute diarrhea in transplant recipients.
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