ArticleMagnetic resonance in medicine2014
Probing lung microstructure with hyperpolarized noble gas diffusion MRI: theoretical models and experimental results.
Article in Magnetic resonance in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Assessment of pulmonary physiological changes caused by aging, cigarette smoking, and COPD with hyperpolarizedEuropean radiology · 2024Article
- Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation.Journal of visualized experiments : JoVE · 2023Article
- Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report.Annals of the American Thoracic Society · 2023Article
- Pulmonary functional MRI: Detecting the structure-function pathologies that drive asthma symptoms and quality of life.Respirology (Carlton, Vic.) · 2022Review
- Functional avoidance-based intensity modulated proton therapy with 4DCT derived ventilation imaging for lung cancer.Journal of applied clinical medical physics · 2021Article
- In vivo methods and applications of xenon-129 magnetic resonance.Progress in nuclear magnetic resonance spectroscopy · 2021Review
- Emphysema Index Based on HyperpolarizedRadiology · 2020Article
- Alveolar Airspace Size in Healthy and Diseased Infant Lungs Measured via Hyperpolarized 3He Gas Diffusion Magnetic Resonance Imaging.Neonatology · 2020Article
- Hyperpolarized gas MRI in pulmonology.The British journal of radiology · 2018Review
- Diffusion lung imaging with hyperpolarized gas MRI.NMR in biomedicine · 2017Review
- Feasibility, tolerability and safety of pediatric hyperpolarizedPediatric radiology · 2016Article
- Functional imaging of the lungs with gas agents.Journal of magnetic resonance imaging : JMRI · 2016Review
- Experimental evidence of age-related adaptive changes in human acinar airways.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- In vivo lung morphometry with accelerated hyperpolarized (3) He diffusion MRI: a preliminary study.Magnetic resonance in medicine · 2015Article
- In vivo lung morphometry with hyperpolarized (3) He diffusion MRI: reproducibility and the role of diffusion-sensitizing gradient direction.Magnetic resonance in medicine · 2015Article
- Probing lung microstructure with hyperpolarized 3He gradient echo MRI.NMR in biomedicine · 2014Article
- Commentary on "The influence of lung airways branching structure and diffusion time on measurements and models of short-range 3He gas MR diffusion".Journal of magnetic resonance (San Diego, Calif. : 1997) · 2014Article
- Magnetic resonance imaging: silicon for the future.Nature nanotechnology · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The introduction of hyperpolarized gases ((3)He and (129)Xe) has opened the door to applications for which gaseous agents are uniquely suited-lung MRI. One of the pulmonary applications, diffusion MRI, relies on measuring Brownian motion of inhaled hyperpolarized gas atoms diffusing in lung airspaces. In this article we provide an overview of the theoretical ideas behind hyperpolarized gas diffusion MRI and the results obtained over the decade-long research. We describe a simple technique based on measuring gas apparent diffusion coefficient (ADC) and an advanced technique, in vivo lung morphometry, that quantifies lung microstructure both in terms of Weibel parameters (acinar airways radii and alveolar depth) and standard metrics (mean linear intercept, surface-to-volume ratio, and alveolar density) that are widely used by lung researchers but were previously available only from invasive lung biopsy. This technique has the ability to provide unique three-dimensional tomographic information on lung microstructure from a less than 15 s MRI scan with results that are in good agreement with direct histological measurements. These safe and sensitive diffusion measurements improve our understanding of lung structure and functioning in health and disease, providing a platform for monitoring the efficacy of therapeutic interventions in clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.