ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2013
On the role of intrinsic and extrinsic forces in early cardiac S-looping.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- morphoHeart: A quantitative tool for integrated 3D morphometric analyses of heart and ECM during embryonic development.PLoS biology · 2025Article
- Generation, Transmission, and Regulation of Mechanical Forces in Embryonic Morphogenesis.Small (Weinheim an der Bergstrasse, Germany) · 2022Review
- Tissue mechanics in stem cell fate, development, and cancer.Developmental cell · 2021Review
- Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells.Developmental cell · 2020Article
- On the Cardiac Loop and Its Failing: Left Ventricular Outflow Tract Obstruction.Journal of the American Heart Association · 2020Review
- Molecular and mechanical signals determine morphogenesis of the cerebral hemispheres in the chicken embryo.Development (Cambridge, England) · 2019Article
- Article
- Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis.Journal of visualized experiments : JoVE · 2018Article
- Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling.Nature communications · 2017Article
- Introduction to provocative questions in left-right asymmetry.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- From cytoskeletal dynamics to organ asymmetry: a nonlinear, regulative pathway underlies left-right patterning.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- How the embryonic chick brain twists.Journal of the Royal Society, Interface · 2016Article
- Interplay between cardiac function and heart development.Biochimica et biophysica acta · 2016Review
- The growth pattern of the human intestine and its mesentery.BMC developmental biology · 2015Article
- Morphomechanics: transforming tubes into organs.Current opinion in genetics & development · 2014Review
- Cardiac looping may be driven by compressive loads resulting from unequal growth of the heart and pericardial cavity. Observations on a physical simulation model.Frontiers in physiology · 2014Article
- Physiological inputs regulate species-specific anatomy during embryogenesis and regeneration.Communicative & integrative biologyArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLooping is a crucial phase during heart development when the initially straight heart tube is transformed into a shape that more closely resembles the mature heart. Although the genetic and biochemical pathways of cardiac looping have been well studied, the biophysical mechanisms that actually effect the looping process remain poorly understood. Using a combined experimental (chick embryo) and computational (finite element modeling) approach, we study the forces driving early s-looping when the primitive ventricle moves to its definitive position inferior to the common atrium.
resultsNew results from our study indicate that the primitive heart has no intrinsic ability to form an s-loop and that extrinsic forces are necessary to effect early s-looping. They support previous studies that established an important role for cervical flexure in causing early cardiac s-looping. Our results also show that forces applied by the splanchnopleure cannot be ignored during early s-looping and shed light on the role of cardiac jelly. Using available experimental data and computer modeling, we successfully developed and tested a hypothesis for the force mechanisms driving s-loop formation.
conclusionsForces external to the primitive heart tube are necessary in the later stages of cardiac looping. Experimental and model results support our proposed hypothesis for forces driving early s-looping.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.