ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2013
Snai1 is important for avian epicardial cell transformation and motility.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- KLF5 inhibits the migration and invasion in cervical cancer cell lines by regulating SNAI1.Cancer biomarkers : section A of Disease markers · 2024Article
- Novel Insights into the Molecular Mechanisms Governing Embryonic Epicardium Formation.Journal of cardiovascular development and disease · 2023Review
- Chrysin-based supramolecular cyclodextrin-calixarene drug delivery system: a novel approach for attenuating cardiac fibrosis in chronic diabetes.Frontiers in pharmacology · 2023Article
- Spatiotemporal single-cell RNA sequencing of developing chicken hearts identifies interplay between cellular differentiation and morphogenesis.Nature communications · 2021Article
- Hypoxia Supports Epicardial Cell Differentiation in Vascular Smooth Muscle Cells through the Activation of the TGFβ Pathway.Journal of cardiovascular development and disease · 2018Article
- HAND2 Target Gene Regulatory Networks Control Atrioventricular Canal and Cardiac Valve Development.Cell reports · 2017Article
- Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease.Journal of clinical medicine · 2016Review
- The Epicardium and the Development of the Atrioventricular Junction in the Murine Heart.Journal of developmental biology · 2014Article
- RNA-seq analysis to identify novel roles of scleraxis during embryonic mouse heart valve remodeling.PloS one · 2014Article
- Transcriptional Control of Cell Lineage Development in Epicardium-Derived Cells.Journal of developmental biology · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFormation of the epicardium requires several cellular processes including migration, transformation, invasion, and differentiation in order to give rise to fibroblast, smooth muscle, coronary endothelial and myocyte cell lineages within the developing myocardium. Snai1 is a zinc finger transcription factor that plays an important role in regulating cell survival and fate during embryonic development and under pathological conditions. However, its role in avian epicardial development has not been examined.
resultsHere we show that Snai1 is highly expressed in epicardial cells from as early as the proepicardial cell stage and its expression is maintained as proepicardial cells migrate and spread over the surface of the myocardium and undergo epicardial-to-mesenchymal transformation in the generation of epicardial-derived cells. Using multiple in vitro assays, we show that Snai1 overexpression in chick explants enhances proepicardial cell migration at Hamburger Hamilton Stage (HH St.) 16, and epicardial-to-mesenchymal transformation, cell migration, and invasion at HH St. 24. Further, we demonstrate that Snai1-mediated cell migration requires matrix metalloproteinase activity, and MMP15 is sufficient for this process.
conclusionsTogether our data provide new insights into the multiple roles that Snai1 has in regulating avian epicardial development.
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