Evidence map›Paper›PMID 23553345›Full record

ArticleAIDS and behavior2013

Aggregate versus day level association between methamphetamine use and HIV medication non-adherence among gay and bisexual men.

Jeffrey T Parsons, William J Kowalczyk, Michael Botsko, Julia Tomassilli, Sarit A Golub

Abstract readComparative Study
In one paragraph

Article in AIDS and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 44 citations in OpenAlex.

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  9. Leukocyte telomere length is not shortened in methamphetamine dependence or methamphetamine-induced psychosis but is increased following traumatic events.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jeffrey T ParsonsCenter for HIV/AIDS Educational Studies and Training (CHEST), New York, NY, USA. jeffrey.parsons@hunter.cuny.edu
William J Kowalczyk
Michael Botsko
Julia Tomassilli
Sarit A Golub
American College of Chest Physicians · USCenter for Children · USThe Graduate Center, CUNY · US

Funding

Intervention Targeting Medication Adherence and Methamphetamine Use for HIV + MenR01DA023395 · NIDA · HUNTER COLLEGE · PI PARSONS, JEFFREY T · 2007 to 2011
$2.6M
NIDA NIH HHS R01 DA023395
6 · The paper itself

Abstract

Methamphetamine use is associated with HIV infection, especially among gay and bisexual men. Methamphetamine use contributes to disease progression both directly, by increasing viral load and damaging the immune system, and indirectly, by decreasing medication adherence. Research examining the association of methamphetamine use and non-adherence has traditionally compared groups of users and nonusers on adherence, compared methamphetamine use between participants above or below some threshold level of adherence (e.g. >90 % dose adherence), or examined aggregate relationships. Using Timeline Follow-back procedures, the present study examined aggregate, threshold, and day-level associations of methamphetamine use with non-adherence in 210 HIV-positive gay and bisexual methamphetamine-using men. Methamphetamine use was not associated with adherence behavior at the aggregate-level, but methamphetamine use on a given day was associated with 2.3 times the odds of non-adherence on that day. Threshold results were equivocal. These data suggest that the methamphetamine and non-adherence relationship is complicated: non-adherence is more likely to occur on days in which methamphetamine is used, but participants reported more non-adherence days in which methamphetamine was not used. This seeming paradox generates questions about the selection of analytical techniques and has important implications for behavioral interventions targeting substance use and adherence among HIV-positive individuals.

Indexed as

Medication AdherenceAdolescentAdultAmphetamine-Related DisordersAnti-HIV AgentsBisexualityCentral Nervous System StimulantsFemaleHealth SurveysHIV InfectionsHomosexualityHumansInterviews as TopicLogistic ModelsMaleMethamphetamineAnti-HIV AgentsCentral Nervous System StimulantsMethamphetamine

Identifiers

PMID23553345
PMCPMC3643207
OpenAlexW2056261079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.