ArticleImmunologic research2013
Toxoplasma gondii: bystander or cofactor in rheumatoid arthritis.
Article in Immunologic research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Toxoplasmosis seroprevalence in rheumatoid arthritis patients: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2018Pooled it
- Possible link betweenAfrican health sciences · 2025Article
- Impact of Experimental Congenital Toxoplasmosis on the Thyroid Gland: Histopathological and Immunobiochemical Indices Assessment.Acta parasitologica · 2025Article
- Seroprevalence of Toxoplasma gondii and Borrelia burgdorferi infections in patients with multiple sclerosis in Poland.Scientific reports · 2024Article
- Plasma Cholinesterase Activity in Patients With Rheumatoid Arthritis and Toxoplasmosis.Cureus · 2023Article
- Article
- Systemic Lupus Erythematosus Risk: The Role of Environmental Factors.Rheumatic diseases clinics of North America · 2022Review
- Association betweenJournal of translational autoimmunity · 2022Review
- Toxoplasma gondii and multiple sclerosis: a population-based case-control study.Scientific reports · 2020Article
- A Transcriptome Analysis: Various Reasons of Adverse Pregnancy Outcomes Caused by AcuteFrontiers in physiology · 2020Article
- Infectious processes and systemic lupus erythematosus.Immunology · 2019Review
- Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China.Infectious diseases of poverty · 2017Article
- Anti-Toxoplasma antibodies in Egyptian rheumatoid arthritis patients.Rheumatology international · 2017Article
- Infections and Systemic Lupus Erythematosus: Binding or Sparring Partners?International journal of molecular sciences · 2015Review
- Infections and systemic lupus erythematosus.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Review
- Autoimmune features in metabolic liver disease: a single-center experience and review of the literature.Clinical reviews in allergy & immunology · 2013Review
- Unraveling the soul of autoimmune diseases: pathogenesis, diagnosis and treatment adding dowels to the puzzle.Immunologic research · 2013Article
- Toxoplasmosis Frequency Rate in Rheumatoid Arthritis Patients in Northeastern Iran.Iranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parasitic infections may induce variable immunomodulatory effects and control of autoimmune disease. Toxoplasma gondii (T. gondii) is a ubiquitous intracellular protozoan that was recently associated with autoimmunity. This study was undertaken to investigate the seroprevalence and clinical correlation of anti-T. gondii antibodies in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). We evaluated sera from European patients with RA (n = 125) and SLE (n = 164) for the prevalence of anti-T. gondii IgG antibodies (ATXAb), as well as other common infections such as Cytomegalovirus, Epstein-Barr, and Rubella virus. The rates of seropositivity were determined utilizing the LIAISON chemiluminescent immunoassays (DiaSorin, Italy). Our results showed a higher seroprevalence of ATXAb in RA patients, as compared with SLE patients [63 vs. 36 %, respectively (p = 0.01)]. The rates of seropositivity of IgG against other infectious agents were comparable between RA and SLE patients. ATXAb-seropositivity was associated with older age of RA patients, although it did not correlate with RA disease activity and other manifestations of the disease. In conclusion, our data suggest a possible link between exposure to T. gondii infection and RA.
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