ArticleEuropean journal of nuclear medicine and molecular imaging2013
Myocardial perfusion reserve in spared myocardium: correlation with infarct size and left ventricular ejection fraction.
Article in European journal of nuclear medicine and molecular imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 12 citations in OpenAlex.
- Refining the Guinea Pig (Cavia porcellus) Cryo-Injury Model for Cardiac Regeneration and Functional Characterization.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Evaluation of left ventricular volumes and ejection fraction byJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Ventricular synchrony is not significantly determined by absolute myocardial perfusion in patients with chronic heart failure: AJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Early risk stratification using Rubidium-82 positron emission tomography in STEMI patients.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Stress myocardial blood flow correlates with ventricular function and synchrony better than myocardial perfusion reserve: A Nitrogen-13 ammonia PET study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Type 2 diabetes mellitus correlates with systolic function during myocardial stress perfusion scanning with Nitrogen-13 ammonia PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Clinical use of quantitative cardiac perfusion PET: rationale, modalities and possible indications. Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM).European journal of nuclear medicine and molecular imaging · 2016Review
- Quantitative Myocardial Perfusion with Dynamic Contrast-Enhanced Imaging in MRI and CT: Theoretical Models and Current Implementation.BioMed research international · 2016Review
- Coronary artery-bronchial artery fistulas: report of two Dutch cases with a review of the literature.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2014Article
- Myocardial perfusion reserve in spared myocardium: one more tessera of the complex mosaic of LV remodelling after myocardial infarction.European journal of nuclear medicine and molecular imaging · 2013Article
- Influence of cardiac decentralization on cardioprotection.PloS one · 2013Article
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Authors and funding
10 authors at 3 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
purposeLeft ventricular ejection fraction (LVEF) after myocardial infarction is considered to be determined by the size of the infarction and residual function of the spared myocardium. Myocardial perfusion reserve (MPR) has been shown to be a strong prognostic factor in patients with ischaemic heart failure, even stronger than LVEF. In the present study, the interrelationship between MPR, LVEF and infarct size was investigated.
methodsIn total, 102 patients with a prior history of myocardial infarction were included. All underwent rest and stress (13)N-ammonia and gated (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) for evaluation of myocardial ischaemia and viability. FDG polar maps were used to determine the size of the infarction. The LVEF was obtained by gated (18)F-FDG PET or another available method within 3 months of the PET scan. MPR was obtained per segment in the spared myocardium.
resultsThe mean age of the subjects was 68 ± 12 years. Global MPR was 1.63 ± 0.51. The mean LVEF was 36 ± 10 % and mean infarct size 23.72 ± 14.8 %. A linear regression model was applied for the analysis considering the LVEF as a dependent variable. All risk factors, mean stress flow, infarct size and MPR were entered as variables. The infarct size (p < 0.001) and MPR (p = 0.04) reached statistical significance. In a multivariate model MPR had a stronger correlation with LVEF than infarct size.
conclusionIn patients with a prior history of myocardial infarction, LVEF is not just related to infarct size but also to MPR in the spared myocardium.
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