ArticlePediatric nephrology (Berlin, Germany)2013
Long-term neurocognitive outcomes of patients with end-stage renal disease during infancy.
Article in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Executive Functioning in Pediatric Solid Organ Transplant Recipients: A Meta-analytic Review.Transplantation · 2020Pooled it
- De novo HLA antibodies after blood transfusion and/or kidney transplant in children with kidney disease.Pediatric nephrology (Berlin, Germany) · 2026Article
- Overcoming anatomical barriers in pediatric kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2026Article
- GDF-15 and uEGF Independently Associate With CKD Progression in Children.Kidney international reports · 2025Article
- Neurodevelopmental Outcomes in Early Childhood Chronic Kidney Disease: Evidence from a Case-control StudyAnnals of neurosciences · 2025Article
- Trends in Timing of Preemptive Kidney Transplantation and Association with Allograft and Survival Outcomes in Children.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Multidisciplinary approach to optimizing long-term outcomes in pediatric kidney transplant recipients: multifaceted needs, risk assessment strategies, and potential interventions.Pediatric nephrology (Berlin, Germany) · 2025Review
- Education and employment outcomes in pediatric chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2024Review
- Neurocognitive Profile in Pediatric Kidney Transplant Candidates: Effects of Medical and Sociodemographic Factors.Research square · 2024Article
- Neurodevelopmental profile of infants and toddlers awaiting a kidney transplant.Pediatric nephrology (Berlin, Germany) · 2024Article
- Clearance and nutrition in neonatal continuous kidney replacement therapy using the Carpediem™ system.Pediatric nephrology (Berlin, Germany) · 2024Observational
- Effect of Executive Function on Health-Related Quality of Life in Children with Chronic Kidney Disease.International journal of nephrology and renovascular disease · 2024Article
- Understanding the impact of pediatric kidney transplantation on cognition: A review of the literature.Pediatric transplantation · 2023Review
- Neurocognitive deficits may not resolve following pediatric kidney transplantation.Pediatric transplantation · 2023Article
- Cognitive and academic outcomes in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2022Article
- Factors Affecting Neurocognitive Function in Children with Chronic Kidney Disease: A Systematic Review.International journal of nephrology and renovascular disease · 2022Review
- Intellectual Functioning of Pediatric Patients with Chronic Kidney Disease: Results from the KNOW-Ped CKD.Journal of Korean medical science · 2021Article
- Multidisciplinarity in Transition Pathways for Patients With Kidney Disease: The Current State of Play.Frontiers in pediatrics · 2021Review
- A longitudinal examination of parent-reported emotional-behavioral functioning of children with mild to moderate chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2020Article
- Neurological Complications and Associated Risk Factors in Children Affected with Chronic Kidney Disease.Children (Basel, Switzerland) · 2020Article
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2 authors.
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Abstract
backgroundEnd-stage renal disease (ESRD) during infancy has been associated with poor short-term neurocognitive outcomes. Limited information exists regarding long-term outcomes.
methodsNeurocognitive outcomes for 12 patients diagnosed with ESRD during the first 16 months of life were assessed. Nine patients (mean age: 11 years) were compared to their healthy siblings (mean age: 10 years) on measures of intellectual and executive functioning, memory, and academic achievement using paired-samples t tests.
resultsPatients' Full Scale IQ (FSIQ) scores (M = 78, SD = 16.1) were significantly lower than sibling controls (M = 94, SD = 18.9; p < 0.03). For patients, FSIQ negatively correlated with total months on dialysis (r = -0.6, p < 0.04), as did WISC-IV Processing Speed (r = -0.6, p < 0.05). Patients' scores on the Metacognition Index of the BRIEF (M = 61.4, SD = 16.3) were significantly higher (indicating greater risk for dysfunction) than siblings (M = 46.7, SD = 6.4; p < 0.04). Patients' scores (M = 84, SD = 19) on the WIAT-II-A Total Achievement were significantly lower than siblings (M = 103, SD = 20, p < 0.01). Younger age at transplant was associated with higher scores on measures of Processing Speed (r = -0.7, p < 0.05), as well as higher scores on measures of executive functioning, memory, and academic achievement.
conclusionsIn summary, patients diagnosed with ESRD as infants had intellectual and metacognitive functioning significantly lower than sibling controls. Fewer months on dialysis and younger age at transplant were associated with better outcomes.
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