ArticleJAMA neurology2013
Neuropathologic basis of age-associated brain atrophy.
Article in JAMA neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed.
- Quantification of blood and CSF volume to predict outcome after aneurysmal subarachnoid hemorrhage.Neurosurgical review · 2024Trial
- Exploring the neuropathological basis of lateral ventricular enlargement in elderly patients with schizophrenia.Psychiatry and clinical neurosciences · 2026Article
- Age-dependent associations of peripheral inflammatory biomarkers with cognition and brain structural abnormalities in patients with Alzheimer's disease and Alzheimer's disease-related mild cognitive impairment.Frontiers in neurology · 2026Article
- Stereological sampling-based estimates of dopaminergic and cholinergic neuron numbers in young adult and aged male and female Fischer 344 × Brown Norway F1 hybrid rats.Frontiers in aging neuroscience · 2026Article
- Baseline Impaired Insight Predicts Longitudinal Brain Atrophy in Alzheimer's Disease and Related Cognitive States: A 30-Month Cohort Study From the ADNI Dataset.Brain and behavior · 2025Article
- Comorbid cerebrovascular and neurodegenerative burden in mild behavioural impairment and their impact on clinical trajectory.Acta neuropsychiatrica · 2025Article
- Abnormal choroid plexus, hippocampus, and lateral ventricles volumes as markers of treatment-resistant major depressive disorder.Psychiatry and clinical neurosciences · 2025Article
- Brain atrophy in heart failure patients following left ventricular assist device implantation or heart transplantation.JHLT open · 2025Article
- Brain health operationalized as brain parenchymal fraction impacts stroke severity both in acute phase and 3 months post stroke.Brain communications · 2025Article
- Smoking predicts brain atrophy in 10,134 healthy individuals and is potentially influenced by body mass index.NPJ dementia · 2025Article
- Cerebrovascular burden and neurodegeneration linked to 15-year odor identification decline in older adults.Frontiers in aging neuroscience · 2025Article
- TDP-43-proteinopathy at the crossroads of tauopathy: on copathology and current and prospective biomarkers.Frontiers in cellular neuroscience · 2025Review
- BIN1 deficiency enhances ULK3-dependent autophagic flux and reduces dendritic size in mouse hippocampal neurons.Autophagy · 2025Article
- Surface-Based Morphometry Analysis of the Cerebral Cortex in Patients With Probable Idiopathic Rapid Eye Movement Sleep Behavior Disorder.Brain and behavior · 2024Article
- Aqueductal CSF stroke volume is associated with the burden of perivascular space enlargement in chronic adult hydrocephalus.Scientific reports · 2024Article
- Unraveling Lifelong Brain Morphometric Dynamics: A Protocol for Systematic Review and Meta-Analysis in Healthy Neurodevelopment and Ageing.Biomedicines · 2023Article
- The influence of age and sex on the absolute cell numbers of the human brain cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Biomarkers of aging.Science China. Life sciences · 2023Review
- Neuroworsening in the Emergency Department Is a Predictor of Traumatic Brain Injury Intervention and Outcome: A TRACK-TBI Pilot Study.Journal of clinical medicine · 2023Article
- Postmortem 7T MRI for guided histopathology and evaluation of cerebrovascular disease.Journal of neuropathology and experimental neurology · 2022Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
importanceWhile brain volume changes are used as surrogate markers for Alzheimer disease neuropathology in clinical studies, the extent to which these changes are due to pathologic features of Alzheimer disease in the aging brain is not well established. This study aims to clarify the neuropathologic correlates of longitudinal brain atrophy.
objectiveTo examine the association between brain atrophy during life and neuropathology in an elderly population.
designAutopsy study of a cohort of elderly individuals.
settingCommunity-based population.
participantsSeventy-one healthy elderly individuals were selected from participants of the Oregon Brain Aging Study for having an autopsy, more than 1 magnetic resonance imaging scan, and the last magnetic resonance imaging scan within 36 months of death. MAIN OUTCOMES AND MEASURES: The associations between brain volume trajectories (ventricular, total brain, and hippocampal) and time interaction terms for neurofibrillary tangles, neuritic plaques, gross infarcts, microinfarcts, amyloid angiopathy, Lewy bodies, APOE ε4 presence, and clinical diagnosis (no cognitive impairment, mild cognitive impairment, or dementia as time-varying covariates) were examined in mixed-effects models, adjusting for duration of follow-up and age at death.
resultsVentricular volume trajectory was significantly associated with age, presence of infarcts, neurofibrillary tangle and neuritic plaque scores, APOE ε4 allele presence, and dementia diagnosis. Total brain volume trajectory was significantly associated with age and mild cognitive impairment diagnosis. Hippocampal volume trajectory was significantly associated with amyloid angiopathy. CONCLUSIONS AND RELEVANCE: Ventricular volume trajectory is more sensitive than total brain and hippocampal volume trajectories as a marker of accruing Alzheimer disease and vascular pathology in elderly individuals. The association between brain volume trajectories and cognitive impairment (mild cognitive impairment and dementia) remained after controlling for the degree of neuropathology and other covariates. This suggests that there may be other factors not measured in this study that could be contributing to brain atrophy in those with cognitive impairment.
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