ArticleJournal of human genetics2013
Five linkage regions each harbor multiple type 2 diabetes genes in the African American subset of the GENNID Study.
Article in Journal of human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Increased Urinary Extracellular Vesicles and Reduced Expression of NEDD4L in Patients With Type 2 Diabetes and Diabetic Nephropathy.Journal of diabetes research · 2026Article
- Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice.Cell death & disease · 2025Article
- Association of acyl-CoA oxidase-like gene polymorphisms with risk, onset age, and beta-cell function of type 1 diabetes in Chinese.Frontiers in endocrinology · 2025Article
- Article
- Genome-wide association analysis of metabolic syndrome quantitative traits in the GENNID multiethnic family study.Diabetology & metabolic syndrome · 2021Article
- Bayesian variable selection for high dimensional predictors and self-reported outcomes.BMC medical informatics and decision making · 2020Article
- Comparative analysis of gene expression profiles in children with type 1 diabetes mellitus.Molecular medicine reports · 2019Article
- Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study.PloS one · 2018Article
- Article
- Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes.BMC genetics · 2017Article
- Genetics of Type 2 Diabetes in African Americans.Current diabetes reports · 2015Review
- An Efficient Stepwise Statistical Test to Identify Multiple Linked Human Genetic Variants Associated with Specific Phenotypic Traits.PloS one · 2015Article
- Natural variation in the histone demethylase, KDM4C, influences expression levels of specific genes including those that affect cell growth.Genome research · 2014Article
- The short isoform of the ubiquitin ligase NEDD4L is a CREB target gene in hepatocytes.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
We previously localized type 2 diabetes (T2D)-susceptibility genes to five chromosomal regions through a genome-wide linkage scan of T2D and age of diagnosis (AOD) in the African American subset of the GENNID sample. To follow up these findings, we repeated the linkage and association analysis using genotypes on an additional 9203 fine-mapping single nucleotide polymorphisms (SNPs) selected to tag genes under the linkage peaks. In each of the five regions, we confirmed linkage and inferred the presence of ≥2 susceptibility genes. The evidence of multiple susceptibility genes consisted of: (1) multiple linkage peaks in four of the five regions; and (2) association of T2D and AOD with SNPs within ≥2 genes in every region. The associated genes included 3 previously reported to associate with T2D or related traits (GRB10, NEDD4L, LIPG) and 24 novel candidate genes, including genes in lipid metabolism (ACOXL) and cell-cell and cell-matrix adhesion (MAGI2, CLDN4, CTNNA2).
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