Evidence map›Paper›PMID 23552580›Full record

ArticleInternational journal of impotence research2013

Effects of long-term high dose testosterone administration on vaginal epithelium structure and estrogen receptor-α and -β expression of young women.

M Baldassarre, F A Giannone, M P Foschini, C Battaglia, P Busacchi, S Venturoli, M C Meriggiola

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in International journal of impotence research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Pooled it
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  15. Female reproductive tract-organ axes.Frontiers in immunology · 2023
    Review
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  18. Attitudes of transgender men and non-binary people to cervical screening: a cross-sectional mixed-methods study in the UK.The British journal of general practice : the journal of the Royal College of General Practitioners · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

M Baldassarre1] Center for Protection of Sexual Health, Physiopathology of Reproduction and Gynecology, Alma Mater Studiorum University of Bologna, Bologna, Italy [2] Center for Applied Biomedical Research (CRBA), S. Orsola-Malpighi University Hospital-NHS Trust, Bologna, Italy [3] Department of Clinical Medicine, Alma Mater Studiorum University of Bologna, Bologna, Italy.
F A Giannone
M P Foschini
C Battaglia
P Busacchi
S Venturoli
M C Meriggiola
University of Bologna · ITPoliclinico S.Orsola-Malpighi · ITIstituto Oncologico Romagnolo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, the effects of long-term testosterone (T) administration on the human vagina are not completely understood. Thus, the aim of this study was to investigate the effects of long-term T treatment on vaginal tissue histology, estrogen receptor alpha (ERα) and beta (ERβ) expression and proliferation in female to male transsexual subjects (FtM). We compared vaginal samples from FtM subjects with those of premenopausal women (PrM) and postmenopausal women (M) not receiving any hormonal treatment for at least 2 years. Vaginal tissue samples from 16 FtM subjects treated with T (intramuscular injections of 100 mg Testoviron Depot/7-10 days for at least 1 year), undergoing sex reassignment surgery, and 16 PrM and 16 M subjects undergoing a vaginal hysterectomy for prolapse, were collected. For each sample, morphology, glycogen content, proliferation (ki-67), ERα and ERβ expression were evaluated. Vaginal samples from FtM showed a loss of normal architecture of the epithelium, intermediate and superficial layers were completely lost, and glycogen content was depleted. T administration resulted in a strong proliferation reduction when compared with both M and PrM subjects. Stromal and epithelial ERα as well as ERβ were significantly decreased in FtM when compared with PrM subjects. In conclusion, our data suggests that systemic T administration at supraphysiological dosage, determines profound changes in histomorphology and reduces ERs expression and proliferation of vaginal epithelium.

Indexed as

Gender-Affirming ProceduresAdultAgedDrug CombinationsEpitheliumEstrogen Receptor alphaEstrogen Receptor betaFemaleGlycogenHumansKi-67 AntigenMiddle AgedPostmenopausePremenopauseTestosteroneTranssexualismDrug CombinationsEstrogen Receptor alphaEstrogen Receptor betaGlycogenKi-67 AntigenTestosteroneTestoviron-depot

Identifiers

PMID23552580
OpenAlexW1984905430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.