ArticleInternational journal of impotence research2013
A clinical study to assess the effectiveness of a hyaluronic acid-based procedure for treatment of premature ejaculation.
Article in International journal of impotence research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Clinical use of hyaluronic acid in andrology: A review.Andrology · 2022Pooled it
- Hyaluronic acid versus botulinum a toxin injection in the treatment of premature ejaculation: A comparative study.Scientific reports · 2025Trial
- Hyaluronic acid injection in glans penis for treatment of premature ejaculation: a randomized controlled cross-over study.International journal of impotence research · 2019Trial
- A hyaluronic acid- and chondroitin sulfate-based medical device improves gastritis pain, discomfort, and endoscopic features.Drug delivery and translational research · 2018Trial
- Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures.Drug design, development and therapy · 2013Trial
- Managing residual volumes in penile girth enhancement with hyaluronic acid fillers: a case series and literature review.International journal of impotence research · 2026Review
- Randomized controlled trial comparing deep dermal glanular hyaluronic acid injection versus oral dapoxetine in management of premature ejaculation.International urology and nephrology · 2026Article
- Surgical treatment of premature ejaculation: a narrative review.International journal of impotence research · 2024Review
- Dapoxetine versus glans penis injection with hyaluronic acid gel in treatment of premature ejaculation.Arab journal of urology · 2024Article
- The role of surgical therapy in the management of premature ejaculation: a narrative review.Translational andrology and urology · 2023Review
- Hyaluronic acid injection to coronal sulcus of the penis for the treatment of premature ejaculation: a retrospective observational study.BMC urology · 2023Observational
- The Application of Hyaluronic Acid Injections in Functional and Aesthetic Andrology: A Narrative Review.Gels (Basel, Switzerland) · 2023Review
- Outcome of hyaluronic acid gel injection in glans penis for treatment of lifelong premature ejaculation: A pilot study.Arab journal of urology · 2023Article
- Glans penis augmentation: when, how, and why?International journal of impotence research · 2022Review
- Glans penis augmentation using hyaluronic acid for the treatment of premature ejaculation: a narrative review.Translational andrology and urology · 2020Review
- Comment on "Hyaluronic acid injection in glans penis for treatment of premature ejaculation: a randomized controlled cross-over study".International journal of impotence research · 2020Article
- Progresses in pharmaceutical and surgical management of premature ejaculation.Chinese medical journal · 2019Review
- Experimental and Clinical Efficacy of Two Hyaluronic Acid-based Compounds of Different Cross-Linkage and Composition in the Rejuvenation of the Skin.Pharmaceutical research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Premature ejaculation is a sexual debilitating condition affecting a large number of men worldwide and leading to important dysfunctions influencing the patients' affective and emotional life. Hyaluronic acid is a natural and safe compound that has been widely used not only in the aesthetic medicine clinic, but also for treatment of osteoarthritis. The present study shows the effectiveness of a hyaluronic acid-based procedure for treatment of premature ejaculation. A hundred and ten male patients were treated with hyaluronic acid injections in the deep dermis of their glans penis to increase the volume and the circumference of their penis to prevent male premature ejaculation and improve the patients' and their partners' sexual satisfaction. The intravaginal ejaculation latency time increased significantly from a baseline value of 88.34±3.14 s to 293.14±8.16 s after 6 months from the procedure. Maximal glandular circumference increased from 98.51±0.71 mm to 114.35±0.66 mm after 6 months from the procedure. At 6-month follow-up, patients' self-rated satisfaction was 5.3±0.07 (range: 4-6). At the follow-up, partners' self-rated satisfaction was 5.1±0.09 (range: 3-6). The present clinical study showed that hyaluronic acid injection is a promising treatment for premature ejaculation. The effect of the procedure in the long-term follow-up needs to be clarified.
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Registered trials
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