ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2013
Phenotypic and molecular differences between rats selectively bred to voluntarily run high vs. low nightly distances.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Comparative effects of voluntary and forced exercise on cognitive performance, thyroid function, and hippocampal integrity in a rat model of post-traumatic stress disorder.IBRO neuroscience reports · 2026Article
- Selective breeding for physical inactivity produces cognitive deficitsFrontiers in aging neuroscience · 2023Article
- Acute Wheel-Running Increases Markers of Stress and Aversion-Related Signaling in the Basolateral Amygdala of Male Rats.Journal of functional morphology and kinesiology · 2022Article
- The Importance of Motivation to Older Adult Physical and Cognitive Exercise Program Development, Initiation, and Adherence.Frontiers in aging · 2022Article
- Muscle Fiber Type Transitions with Exercise Training: Shifting Perspectives.Sports (Basel, Switzerland) · 2021Review
- Five months of voluntary wheel running downregulates skeletal muscle LINE-1 gene expression in rats.American journal of physiology. Cell physiology · 2019Article
- Rats Selectively Bred for High Voluntary Physical Activity Behavior are Not Protected from the Deleterious Metabolic Effects of a Western Diet When Sedentary.Current developments in nutrition · 2019Article
- Overexpression of Protein Kinase Inhibitor Alpha Reverses Rat Low Voluntary Running Behavior.Molecular neurobiology · 2019Article
- Inter-individual variation in adaptations to endurance and resistance exercise training: genetic approaches towards understanding a complex phenotype.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms.Physiological reviews · 2017Review
- Loss of Cdk5 function in the nucleus accumbens decreases wheel running and may mediate age-related declines in voluntary physical activity.The Journal of physiology · 2017Article
- Impact of external pneumatic compression target inflation pressure on transcriptome-wide RNA expression in skeletal muscle.Physiological reports · 2016Article
- Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running.Drug and alcohol dependence · 2016Article
- Effects of intrinsic aerobic capacity and ovariectomy on voluntary wheel running and nucleus accumbens dopamine receptor gene expression.Physiology & behavior · 2016Article
- Sex-dependent effects of developmental exposure to bisphenol A and ethinyl estradiol on metabolic parameters and voluntary physical activity.Journal of developmental origins of health and disease · 2015Article
- Comparative adaptations in oxidative and glycolytic muscle fibers in a low voluntary wheel running rat model performing three levels of physical activity.Physiological reports · 2015Article
- Cocaine-induced locomotor activity in rats selectively bred for low and high voluntary running behavior.Psychopharmacology · 2015Article
- Rapid Alterations in Perirenal Adipose Tissue Transcriptomic Networks with Cessation of Voluntary Running.PloS one · 2015Article
- Striatal enkephalinergic differences in rats selectively bred for intrinsic running capacity.Brain research · 2014Article
- Unique transcriptomic signature of omental adipose tissue in Ossabaw swine: a model of childhood obesity.Physiological genomics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
The purpose of the present study was to partially phenotype male and female rats from generations 8-10 (G8-G10) that had been selectively bred to possess low (LVR) vs. high voluntary running (HVR) behavior. Over the first 6 days with wheels, 34-day-old G8 male and female LVRs ran shorter distances (P < 0.001), spent less time running (P < 0.001), and ran slower (P < 0.001) than their G8 male and female HVR counterparts, respectively. HVR and LVR lines consumed similar amounts of standard chow with or without wheels. No inherent difference existed in PGC-1α mRNA in the plantaris and soleus muscles of LVR and HVR nonrunners, although G8 LVR rats inherently possessed less NADH-positive superficial plantaris fibers compared with G8 HVR rats. While day 28 body mass tended to be greater in both sexes of G9-G10 LVR nonrunners vs. G9-G10 HVR nonrunners (P = 0.06), body fat percentage was similar between lines. G9-G10 HVRs had fat mass loss after 6 days of running compared with their prerunning values, while LVR did not lose or gain fat mass during the 6-day voluntary running period. RNA deep sequencing efforts in the nucleus accumbens showed only eight transcripts to be >1.5-fold differentially expressed between lines in HVR and LVR nonrunners. Interestingly, HVRs presented less Oprd1 mRNA, which ties in to potential differences in dopaminergic signaling between lines. This unique animal model provides further evidence as to how exercise may be mechanistically regulated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.