Evidence map›Paper›PMID 23552363›Full record

ArticleEnvironmental health perspectives2013

Determinants and within-person variability of urinary cadmium concentrations among women in northern California.

Robert B Gunier, Pamela L Horn-Ross, Alison J Canchola, Christine N Duffy, Peggy Reynolds, Andrew Hertz, Erika Garcia, Rudolph P Rull

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
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  8. Determinants of Erythrocyte Lead Levels in 454 Adults in Florence, Italy.International journal of environmental research and public health · 2019
    Article
  9. Article
  10. Article
  11. Cadmium Exposure Impairs Cognition and Olfactory Memory in Male C57BL/6 Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2018
    Article
  12. Prenatal cadmium exposure and preterm low birth weight in China.Journal of exposure science & environmental epidemiology · 2017
    Article
  13. Temporal variability of urinary cadmium in spot urine samples and first morning voids.Journal of exposure science & environmental epidemiology · 2017
    Article
  14. Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Robert B GunierCancer Prevention Institute of California, Berkeley, California, USA.
Pamela L Horn-Ross
Alison J Canchola
Christine N Duffy
Peggy Reynolds
Andrew Hertz
Erika Garcia
Rudolph P Rull
Cancer Prevention Institute of California · US

Funding

CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
REGIONAL VARIATIONS IN BREAST CANCER RATES IN CALIFORNIAU01CA081789 · NCI · PUBLIC HEALTH INSTITUTE · PI REYNOLDS, PEGGY · 1999 to 2001
$980k
NCI NIH HHS R01 CA077398NCI NIH HHS R01CA77398NCI NIH HHS U01 CA081789NCI NIH HHS U01-CA81789
6 · The paper itself

Abstract

backgroundCadmium (Cd) is a toxic metal associated with increased morbidity and mortality. Urinary Cd (U-Cd) concentration is considered a biomarker of long-term exposure.

objectivesOur objectives were to evaluate the within-person correlation among repeat samples and to identify predictors of U-Cd concentrations.

methodsU-Cd concentrations (micrograms per liter) were measured in 24-hr urine samples collected from 296 women enrolled in the California Teachers Study in 2000 and a second 24-hr sample collected 3-9 months later from 141 of the participants. Lifestyle and sociodemographic characteristics were obtained via questionnaires. The Total Diet Study database was used to quantify dietary cadmium intake based on a food frequency questionnaire. We estimated environmental cadmium emissions near participants' residences using a geographic information system.

resultsThe geometric mean U-Cd concentration was 0.27 µg/L and the range was 0.1-3.6 µg/L. The intraclass correlation among repeat samples from an individual was 0.50. The use of a single 24-hr urine specimen to characterize Cd exposure in a case-control study would result in an observed odds ratio of 1.4 for a true odds ratio of 2.0. U-Cd concentration increased with creatinine, age, and lifetime pack-years of smoking among ever smokers or lifetime intensity-years of passive smoking among nonsmokers, whereas it decreased with greater alcohol consumption and number of previous pregnancies. These factors explained 42-44% of the variability in U-Cd concentrations.

conclusionU-Cd levels varied with several individual characteristics, and a single measurement of U-Cd in a 24-hr sample did not accurately reflect medium- to long-term body burden.

Indexed as

Body BurdenEnvironmental MonitoringAgedAged, 80 and overCadmiumCaliforniaFemaleHumansMiddle AgedSmokingCadmium

Identifiers

PMID23552363
PMCPMC3672909
OpenAlexW2146227671

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.