Evidence map›Paper›PMID 23552182›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013

DHEA enhances emotion regulation neurocircuits and modulates memory for emotional stimuli.

Rebecca K Sripada, Christine E Marx, Anthony P King, Nirmala Rajaram, Sarah N Garfinkel, James L Abelson, Israel Liberzon

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Rebecca K SripadaDepartment of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA. rekaufma@umich.edu
Christine E Marx
Anthony P King
Nirmala Rajaram
Sarah N Garfinkel
James L Abelson
Israel Liberzon
University of Michigan–Ann Arbor · USBrighton and Sussex Medical School · GBDuke University · US

Funding

Cognition-Emotion-HPA Interaction: Translation NetworkR24MH075999 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIBERZON, ISRAEL · 2006 to 2008
$1.1M
NIMH NIH HHS R24 MH075999
6 · The paper itself

Abstract

Dehydroepiandrosterone (DHEA) is a neurosteroid with anxiolytic, antidepressant, and antiglucocorticoid properties. It is endogenously released in response to stress, and may reduce negative affect when administered exogenously. Although there have been multiple reports of DHEA's antidepressant and anxiolytic effects, no research to date has examined the neural pathways involved. In particular, brain imaging has not been used to link neurosteroid effects to emotion neurocircuitry. To investigate the brain basis of DHEA's impact on emotion modulation, patients were administered 400 mg of DHEA (N=14) or placebo (N=15) and underwent 3T fMRI while performing the shifted-attention emotion appraisal task (SEAT), a test of emotional processing and regulation. Compared with placebo, DHEA reduced activity in the amygdala and hippocampus, enhanced connectivity between the amygdala and hippocampus, and enhanced activity in the rACC. These activation changes were associated with reduced negative affect. DHEA reduced memory accuracy for emotional stimuli, and also reduced activity in regions associated with conjunctive memory encoding. These results demonstrate that DHEA reduces activity in regions associated with generation of negative emotion and enhances activity in regions linked to regulatory processes. Considering that activity in these regions is altered in mood and anxiety disorders, our results provide initial neuroimaging evidence that DHEA may be useful as a pharmacological intervention for these conditions and invite further investigation into the brain basis of neurosteroid emotion regulatory effects.

Indexed as

AdolescentAdultAmygdalaBrain MappingDehydroepiandrosteroneDouble-Blind MethodEmotionsGyrus CinguliHippocampusHumansMaleMemoryNeural PathwaysNeurotransmitter AgentsDehydroepiandrosteroneNeurotransmitter Agents

Identifiers

PMID23552182
PMCPMC3717538
OpenAlexW2048590846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.