ArticleSchizophrenia bulletin2013
Treating older adults with schizophrenia: challenges and opportunities.
Article in Schizophrenia bulletin, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Psychosocial Interventions for Older Adults With Severe Mental Illness: A Systematic Scoping Review and Meta-analysis.Schizophrenia bulletin · 2026Pooled it
- Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial.Lancet (London, England) · 2015Trial
- Clinical outcomes in first-episode psychoses: does age at admission matter?European archives of psychiatry and clinical neuroscience · 2026Article
- Clinical outcomes in first-episode schizophrenia: identifying predictors of relapse.Social psychiatry and psychiatric epidemiology · 2026Article
- Associations of neuromelanin in the substantia nigra with antipsychotic response in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Clinical practice guidelines for management of schizophrenia in India: A comprehensive overview.Indian journal of psychiatry · 2026Article
- Psychosocial Interventions Impact on Cardiometabolic, Neurobiological, Behavioral, and Immune Outcomes in People With a Serious Mental Illness: A Systematic Review.Health science reports · 2025Review
- Longitudinal trends in schizophrenia among older adults: a 12-year analysis of prevalence and healthcare utilization in South Korea.Schizophrenia (Heidelberg, Germany) · 2025Article
- Utility of Digital Phenotyping Based on Wrist Wearables and Smartphones in Psychosis: Observational Study.JMIR mHealth and uHealth · 2025Observational
- Physical health challenges faced by elders with severe mental illness: population-based retrospective cohort study.BJPsych open · 2024Article
- Life Course Perspectives of Aging With Schizophrenia Spectrum Disorders in Psychiatric and Long-Term Care Facilities.The Gerontologist · 2024Article
- Digital Phenotyping in Adults with Schizophrenia: A Narrative Review.Current psychiatry reports · 2023Review
- The Difficult Path to the Discovery of Novel Treatments in Psychiatric Disorders.Advances in neurobiology · 2023Article
- Mortality in Schizophrenia-Spectrum Disorders: Recent Advances in Understanding and Management.Healthcare (Basel, Switzerland) · 2022Article
- Middle-aged and older people with urgent, unaware, and unmet mental health care needs: Practitioners' viewpoints from outside the formal mental health care system.BMC health services research · 2022Article
- Association between the loudness dependence of auditory evoked potentials and age in patients with schizophrenia and depression.The Journal of international medical research · 2022Article
- Predicting Psychotic Relapse in Schizophrenia With Mobile Sensor Data: Routine Cluster Analysis.JMIR mHealth and uHealth · 2022Article
- Process of Deinstitutionalization of Aging Individuals With Severe and Disabling Mental Disorders: A Review.Frontiers in psychiatry · 2022Review
- A Group Videogame-Based Physical Activity Program Improves Walking Speed in Older Adults Living With a Serious Mental Illness.Innovation in aging · 2022Article
- Predictors of admission to an assertive outreach service for psychosis in Lebanon.PLOS global public health · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Schizophrenia affects people of all age groups. Treatment plans for older adults with schizophrenia must consider the effects of age on the course of the illness as well as on the response to antipsychotics and to psychosocial interventions. Positive symptoms of schizophrenia tend to become less severe, substance abuse becomes less common, and mental health functioning often improves. Hospitalizations are more likely to be due to physical problems rather than psychotic relapses. Physical comorbidity is a rule, however, and older age is a risk factor for most side effects of antipsychotics, including metabolic syndrome and movement disorders. We recently reported high rates of adverse events and medication discontinuation along with limited effectiveness of commonly used atypical antipsychotics in older adults. Psychosocial interventions such as cognitive behavioral social skills training are efficacious in improving functioning in older adults with schizophrenia. In formulating treatment plans for this population, a balanced approach combining cautious antipsychotic medication use with psychosocial interventions is recommended. Antipsychotic medications should generally be used in lower doses in older adults. Close monitoring for side effects and effectiveness of the medications and a watchful eye on their risk:benefit ratio are critical. In a minority of patients it may be possible to discontinue medications. Sustained remission of schizophrenia after decades of illness is not rare, especially in persons who receive appropriate treatment and psychosocial support-there can be light at the end of a long tunnel.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.