ArticleNature communications2013
Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Review
- New findings on the orientation of the mouse anterior-posterior (A-P) axis before and during the initiation of gastrulation using a more refined embryo staging.Biochemistry and biophysics reports · 2024Article
- The beginning of becoming a human.Aging · 2024Review
- Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre.Nature communications · 2021Article
- EGF suppresses the expression of miR-124a in pancreatic β cell lines via ETS2 activation through the MEK and PI3K signaling pathways.International journal of biological sciences · 2019Article
- Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1.Nature communications · 2017Article
- The epigenetic modifier Fam208a is required to maintain epiblast cell fitness.Scientific reports · 2017Article
- ETS transcription factors in embryonic vascular development.Angiogenesis · 2016Review
- Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition.Nucleic acids research · 2016Article
- Sonic hedgehog through Gli2 and Gli3 is required for the proper development of placental labyrinth.Cell death & disease · 2015Article
- Article
- Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Transcriptional regulators of the trophoblast lineage in mammals with hemochorial placentation.Reproduction (Cambridge, England) · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although extraembryonic ectoderm trophoblast signals the embryo for primitive streak initiation, a prerequisite for gastrulation, it is unknown whether it also signals for the progression of gastrulation after primitive streak initiation. Here, using Ets2-/- mice, we show that trophoblast signalling is also required in vivo for primitive streak elongation, completion of intraembryonic mesoderm epithelial-mesenchymal transition and the development of anterior primitive streak derivatives such as the node. We show that Ets2-dependent trophoblast signalling is required for the maintenance of high levels of Nodal and Wnt3 expression in the epiblast and for the induction of Snail expression in the primitive streak, between embryonic day 6.3 and 6.7. Within extraembryonic ectoderm trophoblast, Ets2 maintains the expression of the transcription factors Elf5, Cdx2 and Eomes, and that of the signalling molecule Bmp4. We propose a model that provides a genetic explanation as to how Ets2 in trophoblast mediates the progression of gastrulation within the epiblast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.