ArticleNature communications2013
Mass spectrometric analysis of mono- and multi-phosphopeptides by selective binding with NiZnFe₂O₄ magnetic nanoparticles.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Atomic-level cation occupation and magnetic properties of CeRSC advances · 2025Article
- Bifunctional MNPs@UIO-66-Arg core-shell-satellite nanocomposites for enrichment of phosphopeptides.Mikrochimica acta · 2024Article
- Monodisperse TiMikrochimica acta · 2022Article
- Dual-Functional Ti(IV)-IMAC Material Enables Simultaneous Enrichment and Separation of Diverse Glycopeptides and Phosphopeptides.Analytical chemistry · 2021Article
- Optical chemosensors for the detection of proximally phosphorylated peptides and proteins.RSC chemical biology · 2021Review
- TiMikrochimica acta · 2021Article
- Biomedical applications of dendritic fibrous nanosilica (DFNS): recent progress and challenges.RSC advances · 2020Review
- A polymer monolith composed of a perovskite and cucurbit[6]uril hybrid for highly selective enrichment of phosphopeptides prior to mass spectrometric analysis.Mikrochimica acta · 2019Article
- Hydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides.Nature communications · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selective isolation of mono- and multi-phosphorylated peptides is important for understanding how a graded protein kinase or phosphatase signal can precisely modulate the on and off states of signal transduction pathways. Here we report that metal ions at exposed octahedral sites of nano-ferrites, including Fe3O4, NiFe₂O₄, ZnFe₂O₄ and NiZnFe₂O₄, have distinctly selective coordination abilities with mono- and multi- phosphopeptides. Due to their intrinsic magnetic properties and high surface area to volume ratios, these nanoparticles enable the rapid isolation of mono- and multi-phosphopeptides by an external magnetic field. Model phosphoprotein α-casein and two synthesized mono- and di-phosphopeptides have been chosen for proof-of-principle demonstrations, and these nanoparticles have also been applied to phosphoproteome profiling of zebrafish eggs. It is shown that NiZnFe₂O₄ is highly selective for multi-phosphopeptides. In contrast, Fe₃O₄, NiFe₂O₄ and ZnFe₂O₄ can bind with both mono- and multi-phosphopeptides with relatively stronger affinity towards mono-phosphopeptides.
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