ArticleAddiction biology2014
Reinstatement in a cocaine versus food choice situation: reversal of preference between drug and non-drug rewards.
Article in Addiction biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- A Review of Behavioral Economic Manipulations Affecting Drug versus Nondrug Choice in Rats.Perspectives on behavior science · 2025Review
- A large-scale c-Fos brain mapping study on extinction of cocaine-primed reinstatement.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Intermittent access cocaine self-administration produces context-specific escalation and increased motivation.Drug and alcohol dependence · 2023Article
- Individual differences in cocaine seeking during voluntary abstinence predicts cocaine relapse and the circuitry mediating relapse.Psychopharmacology · 2022Article
- The impact of caloric availability on eating behavior and ultra-processed food reward.Appetite · 2022Article
- Animal Models of the Behavioral Symptoms of Substance Use Disorders.Cold Spring Harbor perspectives in medicine · 2021Review
- Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Improving translation of animal models of addiction and relapse by reverse translation.Nature reviews. Neuroscience · 2020Review
- Opening the cocaine economy by providing within-session access to a cheaper source of cocaine makes demand for it more elastic.Behavioural pharmacology · 2020Article
- Non-pharmacological factors that determine drug use and addiction.Neuroscience and biobehavioral reviews · 2020Review
- Inflexible habitual decision-making during choice between cocaine and a nondrug alternative.Translational psychiatry · 2019Article
- Understanding Addiction Using Animal Models.Frontiers in behavioral neuroscience · 2019Article
- Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Essential values of cocaine and non-drug alternatives predict the choice between them.Addiction biology · 2017Article
- Heroin and saccharin demand and preference in rats.Drug and alcohol dependence · 2017Article
- Social Stress-Induced Alterations in CRF Signaling in the VTA Facilitate the Emergence of Addiction-like Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Cocaine can generate a stronger conditioned reinforcer than food despite being a weaker primary reinforcer.Addiction biology · 2016Article
- Choosing Under the Influence: A Drug-Specific Mechanism by Which the Setting Controls Drug Choices in Rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Persistent palatable food preference in rats with a history of limited and extended access to methamphetamine self-administration.Addiction biology · 2015Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Recent studies show that when given a mutually exclusive choice between cocaine and food, rats almost exclusively choose food. The present experiment investigated potential shifts in preference between levers associated with either food or cocaine that might occur during extinction (food and cocaine no longer available) and during footshock-induced, cocaine-primed and food-primed reinstatement. During self-administration sessions where food and cocaine were simultaneously available, rats demonstrated a stable food preference, choosing food over cocaine on 83% of trials. During extinction when neither reinforcer was available, no preference between levers was evident and responding decreased until rats responded on the previously food- and cocaine-associated levers at equally low rates. Footshock resulted in a non-specific reinstatement of responding upon both levers, while cocaine priming resulted in a significant preference for cocaine seeking over food seeking. This suggests that the mechanism underlying footshock-induced reinstatement is distinct from that of cocaine-primed reinstatement. Food priming engendered a mild, non-specific increase in responding on both levers. Although rats generally prefer food over cocaine when presented with a choice between these primary reinforcers, the present results suggest that in certain situations, cocaine-seeking behavior prevails over food-seeking behavior.
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Registered trials
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