ArticleBipolar disorders2013
Mood lability among offspring of parents with bipolar disorder and community controls.
Article in Bipolar disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Offspring of mothers with bipolar disorder: a systematic review considering personality features.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Pooled it
- Evidence Base Update for Questionnaires of Emotion Regulation and Reactivity for Children and Adolescents.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Pooled it
- Sleep alterations as a predictor of bipolar disorder among offspring of parents with bipolar disorder: a systematic review and meta-analysis.Trends in psychiatry and psychotherapyPooled it
- Mood Instability in Youth at High Risk for Bipolar Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2022Trial
- Affective instability and the course of bipolar depression: results from the STEP-BD randomised controlled trial of psychosocial treatment.The British journal of psychiatry : the journal of mental science · 2016Trial
- A familial risk enriched cohort as a platform for testing early interventions to prevent severe mental illness.BMC psychiatry · 2014Trial
- Mood instability as a transdiagnostic predictor of cannabis use in attention-deficit/hyperactivity disorder and depression: A natural language processing analysis of electronic health records from 13,025 adolescents.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Article
- Underlying biological mechanisms of emotion dysregulation in bipolar disorder.Frontiers in psychiatry · 2025Review
- Psychometric property study of the Affective Lability Scale-short form in Chinese patients with mood disorders.Frontiers in psychiatry · 2023Article
- Social impairment in relation to clinical symptoms in youth at high risk for bipolar disorder.Early intervention in psychiatry · 2022Article
- Characterization of affective lability across subgroups of psychosis spectrum disorders.International journal of bipolar disorders · 2021Article
- Mindfulness-based intervention to decrease mood lability in at-risk youth: Preliminary evidence for changes in resting state functional connectivity.Journal of affective disorders · 2020Article
- Affective lability across psychosis spectrum disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Demographic and Clinical Characteristics, Including Subsyndromal Symptoms Across Bipolar-Spectrum Disorders in Adolescents.Journal of child and adolescent psychopharmacology · 2020Article
- Affective lability in offspring of parents with major depressive disorder, bipolar disorder and schizophrenia.European child & adolescent psychiatry · 2020Article
- Network analysis of mood symptoms in adolescents with or at high risk for bipolar disorder.Bipolar disorders · 2020Article
- Clinical, cortical thickness and neural activity predictors of future affective lability in youth at risk for bipolar disorder: initial discovery and independent sample replication.Molecular psychiatry · 2019Article
- Intrinsic functional connectivity correlates of person-level risk for bipolar disorder in offspring of affected parents.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- A double-edged sword? Sub-types of psychological flexibility are associated with distinct psychiatric disorders.Journal of research in personality · 2018Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesEarly identification of bipolar disorder (BP) symptomatology is crucial for improving the prognosis of this illness. Increased mood lability has been reported in BP. However, mood lability is ubiquitous across psychiatric disorders and may be a marker of severe psychopathology and not specific to BP. To clarify this issue, this study examined the prevalence of mood lability and its components in offspring of BP parents and offspring of community control parents recruited through the Pittsburgh Bipolar Offspring Study.
methodsForty-one school-age BP offspring of 38 BP parents, 257 healthy or non-BP offspring of 174 BP parents, and 192 offspring of 117 control parents completed a scale that was developed to evaluate mood lability in youth, i.e., the Children's Affective Lability Scale (CALS).
resultsA factor analysis of the parental CALS, and in part the child CALS, revealed Irritability, Mania, and Anxiety/Depression factors, with most of the variance explained by the Irritability factor. After adjusting for confounding factors (e.g., parental and offspring non-BP psychopathology), BP offspring of BP parents showed the highest parental and child total and factor scores, followed by the non-BP offspring of BP parents, and then the offspring of the controls.
conclusionsMood lability overall and mania-like, anxious/depressed, and particularly irritability symptoms may be a prodromal phenotype of BP among offspring of parents with BP. Prospective studies are warranted to clarify whether these symptoms will predict the development of BP and/or other psychopathology. If confirmed, these symptoms may become a target of treatment and biological studies before BP develops.
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