Evidence map›Paper›PMID 23551728›Full record

ArticleJournal of clinical hypertension (Greenwich, Conn.)2013

Screening for severe obstructive sleep apnea syndrome in hypertensive outpatients.

Indira Gurubhagavatula, Barry G Fields, Christian R Morales, Sharon Hurley, Grace W Pien, Lindsay C Wick, Bethany A Staley, Raymond R Townsend, Greg Maislin

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of clinical hypertension (Greenwich, Conn.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06174558 (Is My Sleep Tracker Tracking my Sleep? Validation of Two Wearable Fitness Sleep Trackers on Sleep Staging and Nocturnal Hypoxemia in Sleep Medicine Patients Referred for Diagnostic Polysomnogram), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06174558 unknown statusnot on this mapstarted 2024, after this paper: background citation

Is My Sleep Tracker Tracking my Sleep? Validation of Two Wearable Fitness Sleep Trackers on Sleep Staging and Nocturnal Hypoxemia in Sleep Medicine Patients Referred for Diagnostic Polysomnogram

TypeobservationalSponsorRespiratory SpecialistsRan2024 to 2024Enrolled86ConditionsObstructive Sleep ApneaArmsSleep Tracking Devices
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017
    Guideline
  3. Clinical Trial Enrollment Enrichment in Resource-Constrained Research Environments: Multivariable Apnea Prediction (MAP) Index in SCIP-PA Trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018
    Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. A Screening Algorithm for Obstructive Sleep Apnea in Pregnancy.Annals of the American Thoracic Society · 2019
    Article
  9. Screening for Obstructive Sleep Apnea in Commercial Drivers Using EKG-Derived Respiratory Power Index.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Indira GurubhagavatulaPulmonary and Critical Care and Sleep Section, Philadelphia VA Medical Center, Philadelphia, PA 19104, USA.
Barry G Fields
Christian R Morales
Sharon Hurley
Grace W Pien
Lindsay C Wick
Bethany A Staley
Raymond R Townsend
Greg Maislin
Canadian Sleep & Circadian Network · CAUniversity of Pennsylvania · US

Funding

TRAINING PROGRAM/RESPIRATORY NEUROBIOLOGY AND SLEEPT32HL007713 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACK, ALLAN I · 1992 to 2022
$11.9M
Screening for Obstructive Sleep Apnea in Commercial DriversR01OH009149 · OH · UNIVERSITY OF PENNSYLVANIA · PI GURUBHAGAVATULA, INDIRA · 2007 to 2009
$945k
Mentored Patient-Oriented Research Career Development AwK23RR016068 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI GURUBHAGAVATULA, INDIRA · 2000 to 2004
$647k
NCRR NIH HHS K23 RR016068NCRR NIH HHS K23 RR16068NHLBI NIH HHS T32 HL007713NHLBI NIH HHS T32 HL07713NIOSH CDC HHS R01 OH009149NIOSH CDC HHS R01-OH009149
6 · The paper itself

Abstract

The authors attempted to validate a 2-stage strategy to screen for severe obstructive sleep apnea syndrome (s-OSAS) among hypertensive outpatients, with polysomnography (PSG) as the gold standard. Using a prospective design, outpatients with hypertension were recruited from medical outpatient clinics. Interventions included (1) assessment of clinical data; (2) home sleep testing (HST); and (3) 12-channnel, in-laboratory PSG. The authors developed models using clinical or HST data alone (single-stage models) or clinical data in tandem with HST (2-stage models) to predict s-OSAS. For each model, area under receiver operating characteristic curves (AUCs), sensitivity, specificity, negative likelihood ratio, and negative post-test probability (NPTP) were computed. Models were then rank-ordered based on AUC values and NPTP. HST used alone had limited accuracy (AUC=0.727, NPTP=2.9%). However, models that used clinical data in tandem with HST were more accurate in identifying s-OSAS, with lower NPTP: (1) facial morphometrics (AUC=0.816, NPTP=0.6%); (2) neck circumference (AUC=0.803, NPTP=1.7%); and Multivariable Apnea Prediction Score (AUC=0.799, NPTP=1.5%) where sensitivity, specificity, and NPTP were evaluated at optimal thresholds. Therefore, HST combined with clinical data can be useful in identifying s-OSAS in hypertensive outpatients, without incurring greater cost and patient burden associated with in-laboratory PSG. These models were less useful in identifying obstructive sleep apnea syndrome of any severity.

Indexed as

Mass ScreeningFemaleHumansHypertensionMaleMiddle AgedOutpatientsPolysomnographyPredictive Value of TestsROC CurveSeverity of Illness IndexSleep Apnea, ObstructiveSymptom Assessment

Identifiers

PMID23551728
PMCPMC3621016
OpenAlexW2008027535

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.