ReviewWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Neutrophil activity in chronic venous leg ulcers--a target for therapy?
Review in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04507724 (The Use of Biochemical Analyzes to Monitor the Development of Wounds), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Use of Biochemical Analyzes to Monitor the Development of Wounds: Part 1: Analysis of Wounds Without VAC Therapy: Part 2: Analysis of Wound Fluids Under VAC Therapy
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Influence of obesity on the outcome of non-surgical periodontal therapy - a systematic review.BMC oral health · 2016Pooled it
- The zebrafish caudal fin amputation model simulates the impact of hyperglycemia on inflammation and regeneration.American journal of translational research · 2025Article
- Nanoscopic and Functional Characterization of Keratinocyte-Originating Exosomes in the Wound Fluid of Non-Diabetic and Diabetic Chronic Wound Patients.Nano today · 2023Article
- Article
- Biofilms in Chronic Wound Infections: Innovative Antimicrobial Approaches Using the In Vitro Lubbock Chronic Wound Biofilm Model.International journal of molecular sciences · 2023Review
- Skin-Derived ABCB5International journal of molecular sciences · 2022Review
- Stem and Somatic Cell Monotherapy for the Treatment of Diabetic Foot Ulcers: Review of Clinical Studies and Mechanisms of Action.Stem cell reviews and reports · 2022Review
- Immune Cells in Cutaneous Wound Healing: A Review of Functional Data from Animal Models.International journal of molecular sciences · 2022Review
- Nanomaterial-Based Therapy for Wound Healing.Nanomaterials (Basel, Switzerland) · 2022Review
- Recent Advances in Nanozymes for Bacteria-Infected Wound Therapy.International journal of nanomedicine · 2022Review
- Evaluation of Wound Healing Activity (Excision Wound Model) of Ointment Prepared from Infusion Extract of Polyherbal Tea Bag Formulation in Diabetes-Induced Rats.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Naoxintong accelerates diabetic wound healing by attenuating inflammatory response.Pharmaceutical biology · 2021Article
- Comprehensive characterization of myeloid cells during wound healing in healthy and healing-impaired diabetic mice.European journal of immunology · 2020Article
- Article
- Pseudomonas aeruginosa rugose small-colony variants evade host clearance, are hyper-inflammatory, and persist in multiple host environments.PLoS pathogens · 2018Article
- Changes in the extracellular matrix surrounding human chronic wounds revealed by 2-photon imaging.International wound journal · 2017Article
- Accelerated Healing of Diabetic Wounds Treated with L-Glutamic acid Loaded Hydrogels Through Enhanced Collagen Deposition and Angiogenesis: An In Vivo Study.Scientific reports · 2017Article
- Suppression of Neutrophil-Mediated Tissue Damage-A Novel Skill of Mesenchymal Stem Cells.Stem cells (Dayton, Ohio) · 2016Article
- The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing.Nature communications · 2015Article
- Adult vascular wall resident multipotent vascular stem cells, matrix metalloproteinases, and arterial aneurysms.Stem cells international · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chronic venous leg ulcers (CVLUs) affect approximately 600,000 people annually in the United States and accrue yearly treatment costs of US $2.5-5 billion. As the population ages, demands on health care resources for CVLU treatments are predicted to drastically increase because the incidence of CVLUs is highest in those ≥65 years of age. Furthermore, regardless of current standards of care, healing complications and high recurrence rates prevail. Thus, it is critical that factors leading to or exacerbating CVLUs be discerned and more effective, adjuvant, evidence-based treatment strategies be utilized. Previous studies have suggested that CVLUs' pathogenesis is related to the prolonged presence of high numbers of activated neutrophils secreting proteases in the wound bed that destroy growth factors, receptors, and the extracellular matrix that are essential for healing. These events are believed to contribute to a chronically inflamed wound that fails to heal. Therefore, the purpose of this project was to review studies from the past 15 years (1996-2011) that characterized neutrophil activity in the microenvironment of human CVLUs for new evidence that could explicate the proposed relationship between excessive, sustained neutrophil activity and CVLUs. We also appraised the strength of evidence for current and potential therapeutics that target excessive neutrophil activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.