ArticleAIDS research and human retroviruses2013
Lipodystrophy and inflammation predict later grip strength in HIV-infected men: the MACS Body Composition substudy.
Article in AIDS research and human retroviruses, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Physical function, grip strength and frailty in people living with HIV in sub-Saharan Africa: systematic review.Tropical medicine & international health : TM & IH · 2017Pooled it
- Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults.The Journal of infectious diseases · 2016Trial
- Handgrip Strength and Clinical Evolution of People Living with HIV: A Mini Narrative Review.Current HIV research · 2024Review
- Alcohol use, physical activity, and muscle strength moderate the relationship between body composition and frailty risk among people living with HIV.Alcoholism, clinical and experimental research · 2022Article
- Frailty Syndrome Is Associated with Poorer Self-Reported Sleep Quality Among Older Persons with Human Immunodeficiency Virus.AIDS research and human retroviruses · 2022Article
- A Unique Gut Microbiome-Physical Function Axis Exists in Older People with HIV: An Exploratory Study.AIDS research and human retroviruses · 2021Article
- Inflammation Strikes Again: Frailty and HIV.Current HIV/AIDS reports · 2018Review
- Muscle power in children, youth and young adults who acquired HIV perinatally.Journal of musculoskeletal & neuronal interactions · 2017Article
- Inflammation, Immune Activation, Immunosenescence, and Hormonal Biomarkers in the Frailty-Related Phenotype of Men With or at Risk for HIV Infection.The Journal of infectious diseases · 2017Article
- Effect of HIV-infection and cumulative viral load on age-related decline in grip strength.AIDS (London, England) · 2016Article
- Risk factors for mortality among malnourished HIV-infected adults eligible for antiretroviral therapy.BMC infectious diseases · 2016Article
- More than osteoporosis: age-specific issues in bone health.Current opinion in HIV and AIDS · 2016Review
- The Silent Epidemic - Frailty and Aging with HIV.Total patient care in HIV & HCV · 2016Article
- Adiponectin and interleukin-6, but not adipose tissue, are associated with worse neurocognitive function in HIV-infected men.Antiviral therapy · 2015Article
- Functional impairment, disability, and frailty in adults aging with HIV-infection.Current HIV/AIDS reports · 2014Article
- Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Body fat changes in HIV-infected persons are associated with increased systemic inflammation and increased mortality. It is unknown whether lipodystrophy is also associated with declines in physical function. Between 2001 and 2003, 33 HIV-infected men with evidence of lipodystrophy (LIPO⁺), 23 HIV-infected men without lipodystrophy (LIPO⁻), and 33 seronegative men were recruited from the Multicenter AIDS Cohort Study (MACS) for the Body Composition substudy. Visceral adipose tissue (VAT) was assessed by quantitative computed tomography. Lean body mass (LBM) and extremity fat were measured by dual-energy x-ray absorptiometry. Insulin resistance was estimated by Homeostatic Model Assessment (HOMA). Serum interleukin (IL)-6, soluble tumor necrosis factor (TNF)-α receptors I and II (sTNFRI and sTNFRII), and highly sensitive C-reactive protein (hs-CRP) concentrations were quantified from archived serum samples. These measurements were correlated with grip strength measured in 2007 using linear regression. At the substudy visit, the LIPO⁺ group had higher HOMA, sTNFRI, sTNFRII, and IL-6 levels than the LIPO⁻ group. In 2007, the LIPO⁺ group had lower median grip strength than the LIPO⁻ group (34.4 vs. 42.7 kg, p=0.002). Multivariable analysis of HIV⁺ men showed older age, lower LBM, higher sTNFRII concentrations, and LIPO⁺ status [adjusted mean difference -4.9 kg (p=0.045)] at the substudy visit were independently associated with lower subsequent grip strength. Inflammation, lower LBM, and lipodystrophy in HIV-infected men were associated with lower subsequent grip strength. These findings suggest that inflammation may contribute to declines in functional performance, independent of age.
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