ArticleMolecular plant-microbe interactions : MPMI2013
Microbe-independent entry of oomycete RxLR effectors and fungal RxLR-like effectors into plant and animal cells is specific and reproducible.
Article in Molecular plant-microbe interactions : MPMI, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- A survey of highly cited studies on plant pathogen effectors during the last two decades (2000-2020).Frontiers in plant science · 2022Review
- Transcriptional Variability Associated With CRISPR-Mediated Gene Replacements at theFrontiers in microbiology · 2021Article
- Arms race: diverse effector proteins with conserved motifs.Plant signaling & behavior · 2019Article
- Article
- A Suppressor/Avirulence Gene Combination inFrontiers in plant science · 2018Article
- Article
- When green and red mycology meet: Impressions from an interdisciplinary forum on virulence mechanisms of phyto- and human-pathogenic fungi.Virulence · 2017Article
- Delivery of cytoplasmic and apoplastic effectors from Phytophthora infestans haustoria by distinct secretion pathways.The New phytologist · 2017Article
- The cell biology of late blight disease.Current opinion in microbiology · 2016Review
- Enhanced resistance in Theobroma cacao against oomycete and fungal pathogens by secretion of phosphatidylinositol-3-phosphate-binding proteins.Plant biotechnology journal · 2016Article
- Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding.Nature communications · 2016Article
- A Small Secreted Virulence-Related Protein Is Essential for the Necrotrophic Interactions of Sclerotinia sclerotiorum with Its Host Plants.PLoS pathogens · 2016Article
- Oomycete interactions with plants: infection strategies and resistance principles.Microbiology and molecular biology reviews : MMBR · 2015Review
- Evaluation of Secretion Prediction Highlights Differing Approaches Needed for Oomycete and Fungal Effectors.Frontiers in plant science · 2015Article
- An immunity-triggering effector from the Barley smut fungus Ustilago hordei resides in an Ustilaginaceae-specific cluster bearing signs of transposable element-assisted evolution.PLoS pathogens · 2014Article
- How do filamentous pathogens deliver effector proteins into plant cells?PLoS biology · 2014Article
- A comparative hidden Markov model analysis pipeline identifies proteins characteristic of cereal-infecting fungi.BMC genomics · 2013Article
- Filamentous plant pathogen effectors in action.Nature reviews. Microbiology · 2013Review
- On the front line: structural insights into plant-pathogen interactions.Nature reviews. Microbiology · 2013Review
- Structures of the flax-rust effector AvrM reveal insights into the molecular basis of plant-cell entry and effector-triggered immunity.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
22 authors.
Funding
Abstract
A wide diversity of pathogens and mutualists of plant and animal hosts, including oomycetes and fungi, produce effector proteins that enter the cytoplasm of host cells. A major question has been whether or not entry by these effectors can occur independently of the microbe or requires machinery provided by the microbe. Numerous publications have documented that oomycete RxLR effectors and fungal RxLR-like effectors can enter plant and animal cells independent of the microbe. A recent reexamination of whether the RxLR domain of oomycete RxLR effectors is sufficient for microbe-independent entry into host cells concluded that the RxLR domains of Phytophthora infestans Avr3a and of P. sojae Avr1b alone are NOT sufficient to enable microbe-independent entry of proteins into host and nonhost plant and animal cells. Here, we present new, more detailed data that unambiguously demonstrate that the RxLR domain of Avr1b does show efficient and specific entry into soybean root cells and also into wheat leaf cells, at levels well above background nonspecific entry. We also summarize host cell entry experiments with a wide diversity of oomycete and fungal effectors with RxLR or RxLR-like motifs that have been independently carried out by the seven different labs that coauthored this letter. Finally we discuss possible technical reasons why specific cell entry may have been not detected by Wawra et al. (2013).
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