ArticleMobile genetic elements2012
Viral evolution: Primordial cellular origins and late adaptation to parasitism.
Article in Mobile genetic elements, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Studying the Evolution of Protein Structure One Superfamily at a Time.Methods in molecular biology (Clifton, N.J.) · 2026Article
- The bubble theory: exploring the transition from first replicators to cells and viruses in a landscape-based scenario.Theory in biosciences = Theorie in den Biowissenschaften · 2024Article
- Pioneering role of RNA in the early evolution of life.Genetics and molecular biology · 2024Article
- A critical analysis of the current state of virus taxonomy.Frontiers in microbiology · 2023Review
- Tale of Viruses in Male Infertility.Advances in experimental medicine and biology · 2022Article
- Silver Nanoparticles as Potential Antiviral Agents.Pharmaceutics · 2021Review
- Coevolutionary and Phylogenetic Analysis of Mimiviral Replication Machinery Suggest the Cellular Origin of Mimiviruses.Molecular biology and evolution · 2021Article
- Multifunctional Immunoadjuvants for Use in Minimalist Nucleic Acid Vaccines.Pharmaceutics · 2021Review
- Investigating the Concept and Origin of Viruses.Trends in microbiology · 2020Review
- The origin and evolution of viruses inferred from fold family structure.Archives of virology · 2020Review
- Bacterial Origin and Reductive Evolution of the CPR Group.Genome biology and evolution · 2020Article
- Postdigital Research in the Time of Covid-19.Postdigital science and education · 2020Article
- Covid-19: When Species and Data Meet.Postdigital science and education · 2020Article
- A Place for Viruses on the Tree of Life.Frontiers in microbiology · 2020Review
- Identification of Capsid/Coat Related Protein Folds and Their Utility for Virus Classification.Frontiers in microbiology · 2017Article
- Do Viruses Exchange Genes across Superkingdoms of Life?Frontiers in microbiology · 2017Article
- Phylogenetic Tracings of Proteome Size Support the Gradual Accretion of Protein Structural Domains and the Early Origin of Viruses from Primordial Cells.Frontiers in microbiology · 2017Article
- A phylogenomic data-driven exploration of viral origins and evolution.Science advances · 2015Article
- DNA transposons have colonized the genome of the giant virus Pandoravirus salinus.BMC biology · 2015Article
- A phylogenomic census of molecular functions identifies modern thermophilic archaea as the most ancient form of cellular life.Archaea (Vancouver, B.C.) · 2014Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Explaining the origin of viruses remains an important challenge for evolutionary biology. Previous explanatory frameworks described viruses as founders of cellular life, as parasitic reductive products of ancient cellular organisms or as escapees of modern genomes. Each of these frameworks endow viruses with distinct molecular, cellular, dynamic and emergent properties that carry broad and important implications for many disciplines, including biology, ecology and epidemiology. In a recent genome-wide structural phylogenomic analysis, we have shown that large-to-medium-sized viruses coevolved with cellular ancestors and have chosen the evolutionary reductive route. Here we interpret these results and provide a parsimonious hypothesis for the origin of viruses that is supported by molecular data and objective evolutionary bioinformatic approaches. Results suggest two important phases in the evolution of viruses: (1) origin from primordial cells and coexistence with cellular ancestors, and (2) prolonged pressure of genome reduction and relatively late adaptation to the parasitic lifestyle once virions and diversified cellular life took over the planet. Under this evolutionary model, new viral lineages can evolve from existing cellular parasites and enhance the diversity of the world's virosphere.
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