Evidence map›Paper›PMID 23550130›Full record

ArticleG3 (Bethesda, Md.)2013

Activation-Induced Cytidine Deaminase Does Not Impact Murine Meiotic Recombination.

Catarina S Cortesao, Raquel F Freitas, Vasco M Barreto

Erratum issuedOpen access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Catarina S CortesaoInstituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.
Raquel F FreitasInstituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.
Vasco M BarretoInstituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal vbarreto@igc.gulbenkian.pt.
Instituto Gulbenkian de Ciência · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activation-induced cytidine deaminase (AID) was first described as the triggering enzyme of the B-cell-specific reactions that edit the immunoglobulin genes, namely somatic hypermutation, gene conversion, and class switch recombination. Over the years, AID was also detected in cells other than lymphocytes, and it has been assigned additional roles in the innate defense against transforming retroviruses, in retrotransposition restriction and in DNA demethylation. Notably, AID expression was found in germline tissues, and in heterologous systems it can induce the double-strand breaks required for the initiation of meiotic recombination and proper gamete formation. However, because AID-deficient mice are fully fertile, the molecule is not essential for meiosis. Thus, the remaining question that we addressed here is whether AID influences the frequency of meiotic recombination in mice. We measured the recombination events in the meiosis of male and female mice F1 hybrids of C57BL/6J and BALB/c, in Aicda

Indexed as

Immunoglobulin Class SwitchingAnimalsB-LymphocytesCytidine DeaminaseGene Expression RegulationMiceMice, Inbred C57BLRecombination, GeneticCytidine DeaminaseAIDcytidine deaminasedouble-strand breaksgermlinemeiotic recombination

Identifiers

PMID23550130
PMCPMC3618351
OpenAlexW2043528493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.