ArticleG3 (Bethesda, Md.)2013
Assembly of the Synaptonemal Complex Is a Highly Temperature-Sensitive Process That Is Supported by PGL-1 During Caenorhabditis elegans Meiosis.
Article in G3 (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- The synapsis checkpoint and the LIN-35/DREAM complex promote temperature stress-induced increases in germline apoptosis in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2025Article
- The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription machinery to initiate piRNA expression within heterochromatic clusters.Nature communications · 2025Article
- The synaptonemal complex component corolla regulates meiotic crossover formation in Drosophila melanogaster.Chromosoma · 2025Article
- piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation.Nature structural & molecular biology · 2025Article
- Impacts of temperature on recombination rate and meiotic success in thermotolerant and cold-tolerant yeast species.Heredity · 2025Article
- A suppressor screenProceedings of the National Academy of Sciences of the United States of America · 2023Article
- A suppressor screenbioRxiv : the preprint server for biology · 2023Article
- Article
- LIN-35 is necessary in both the soma and germline for preserving fertility in Caenorhabditis elegans under moderate temperature stress.PloS one · 2023Article
- Temperature sensitivity of DNA double-strand break repair underpins heat-induced meiotic failure in mouse spermatogenesis.Communications biology · 2022Article
- Heat stress reveals a specialized variant of the pachytene checkpoint in meiosis of Arabidopsis thaliana.The Plant cell · 2022Article
- SYP-5 regulates meiotic thermotolerance in Caenorhabditis elegans.Journal of molecular cell biology · 2021Article
- Article
- Excess crossovers impede faithful meiotic chromosome segregation in C. elegans.PLoS genetics · 2020Article
- Intragenic meiotic recombination in Schizosaccharomyces pombe is sensitive to environmental temperature changes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2020Article
- Dmc1 is a candidate for temperature tolerance during wheat meiosis.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- CRL4 regulates recombination and synaptonemal complex aggregation in the Caenorhabditis elegans germline.PLoS genetics · 2019Article
- Article
- Are the effects of elevated temperature on meiotic recombination and thermotolerance linked via the axis and synaptonemal complex?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Time-Course Analysis of Early Meiotic Prophase Events Informs Mechanisms of Homolog Pairing and Synapsis inGenetics · 2017Article
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5 authors at 2 institutions in 1 country.
Funding
Abstract
Successful chromosome segregation during meiosis depends on the synaptonemal complex (SC), a structure that stabilizes pairing between aligned homologous chromosomes. Here we show that SC assembly is a temperature-sensitive process during Caenorhabditis elegans meiosis. Temperature sensitivity of SC assembly initially was revealed through identification of the germline-specific P-granule component PGL-1 as a factor promoting stable homolog pairing. Using an assay system that monitors homolog pairing in vivo, we showed that depletion of PGL-1 at 25° disrupts homolog pairing. Analysis of homolog pairing at other chromosomal loci in a pgl-1-null mutant revealed a pairing defect similar to that observed in mutants lacking SC central region components. Furthermore, loss of pgl-1 function at temperatures ≥25° results in severe impairment in loading of SC central region component SYP-1 onto chromosomes, resulting in formation of SYP-1 aggregates. SC assembly is also temperature sensitive in wild-type worms, which exhibit similar SYP-1 loading defects and formation of SYP-1 aggregates at temperatures ≥26.5°. Temperature shift analyses suggest that assembly of the SC is temperature sensitive, but maintenance of the SC is not. We suggest that the temperature sensitive (ts) nature of SC assembly may contribute to fitness and adaptation capacity in C. elegans by enabling meiotic disruption in response to environmental change, thereby increasing the production of male progeny available for outcrossing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.