ArticleMobile genetic elements2012
Integrons: Vehicles and pathways for horizontal dissemination in bacteria.
Article in Mobile genetic elements, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed, 168 citations in OpenAlex.
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- First Isolation, Identification, and Whole-Genome Sequencing of a Multidrug-Resistant Bovine-DerivedPathogens (Basel, Switzerland) · 2026Article
- In Silico Genomic Analysis of Antibiotic Resistance Genes Carried by Mobile Genetic Elements inInternational journal of molecular sciences · 2026Article
- Comprehensive Molecular Characterization of Extensively Drug-ResistantPharmaceuticals (Basel, Switzerland) · 2026Article
- Klebsiella pneumoniae in the global AMR: resistance mechanisms and genomic adaptation.World journal of microbiology & biotechnology · 2026Review
- Pathogenomics of multidrug-resistant Escherichia coli from bloodstream infections in South Africa.BMC medical genomics · 2026Article
- A quantitative characterization of antibiotic resistance and its influencing factors in hospital wastewaters across Lebanon.Scientific reports · 2025Article
- Plasmid Genomic Dynamics and One Health: Drivers of Antibiotic Resistance and Pathogenicity.Pathogens (Basel, Switzerland) · 2025Review
- Antimicrobial resistance inScience in One Health · 2025Review
- ESKAPE pathogens: antimicrobial resistance, epidemiology, clinical impact and therapeutics.Nature reviews. Microbiology · 2024Review
- Article
- Comparison of integron mediated antimicrobial resistance in clinical isolates of Escherichia coli from urinary and bacteremic sources.BMC microbiology · 2024Article
- Genomic landscape of NDM-1 producing multidrug-resistant Providencia stuartii causing burn wound infections in Bangladesh.Scientific reports · 2024Article
- Antimicrobial Resistance in CommensalAntibiotics (Basel, Switzerland) · 2023Review
- Comparative Genomic Analysis Reveals the Emergence of ST-231 and ST-395Microorganisms · 2023Article
- Abundant resistome determinants in rhizosphere soil of the wild plant Abutilon fruticosum.AMB Express · 2023Article
- Integrons in the development of antimicrobial resistance: critical review and perspectives.Frontiers in microbiology · 2023Review
- Egg-associatedFrontiers in microbiology · 2023Article
- Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integrons are genetic elements first described at the end of the 1980s. Although most integrons were initially described in human clinical isolates, they have now been identified in many non-clinical environments, such as water and soil. Integrons are present in ≈10% of the sequenced bacterial genomes and are frequently linked to mobile genetic elements (MGEs); particularly the class 1 integrons. Genetic linkage to a diverse set of MGEs facilitates horizontal transfer of class 1 integrons within and between bacterial populations and species. The mechanistic aspects limiting transfer of MGEs will therefore limit the transfer of class 1 integrons. However, horizontal movement due to genes provided in trans and homologous recombination can result in class 1 integron dynamics independent of MGEs. A key determinant for continued dissemination of class 1 integrons is the probability that transferred MGEs will be vertically inherited in the recipient bacterial population. Heritability depends both on genetic stability as well as the fitness costs conferred to the host. Here we review the factors known to govern the dissemination of class 1 integrons in bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.