ArticlemBio2013
Bacterial bioluminescence regulates expression of a host cryptochrome gene in the squid-Vibrio symbiosis.
Article in mBio, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- WORKbiota: A Systematic Review about the Effects of Occupational Exposure on Microbiota and Workers' Health.International journal of environmental research and public health · 2022Pooled it
- Maintaining microbiota across diverse symbiotic organs inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Fecal Microbiota Transplantation in Animals: Therapeutics, Conservation, and Farming.Microorganisms · 2025Review
- An acidic microenvironment produced by the V-type ATPase of Euprymna scolopes promotes specificity during Vibrio fischeri recruitment.Communications biology · 2024Article
- The Role of Gut Microbiota and Circadian Rhythm Oscillation of Hepatic Ischemia-Reperfusion Injury in Diabetic Mice.Biomedicines · 2023Article
- Microbial circadian clocks: host-microbe interplay in diel cycles.BMC microbiology · 2023Review
- Intermittent fasting modulates the intestinal microbiota and improves obesity and host energy metabolism.NPJ biofilms and microbiomes · 2023Article
- Nocturnal Acidification: A Coordinating Cue in theInternational journal of molecular sciences · 2022Review
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- A lasting symbiosis: how Vibrio fischeri finds a squid partner and persists within its natural host.Nature reviews. Microbiology · 2021Review
- A lasting symbiosis: how the Hawaiian bobtail squid finds and keeps its bioluminescent bacterial partner.Nature reviews. Microbiology · 2021Review
- Animal development in the microbial world: The power of experimental model systems.Current topics in developmental biology · 2021Review
- Review
- The cytokine MIF controls daily rhythms of symbiont nutrition in an animal-bacterial association.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The beneficial effects of intermittent fasting: an update on mechanism, and the role of circadian rhythm and gut microbiota.Hepatobiliary surgery and nutrition · 2020Review
- The impact of persistent colonization byThe Journal of experimental biology · 2020Article
- Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism.Trends in endocrinology and metabolism: TEM · 2020Review
- Diversity of Light Sensing Molecules and Their Expression During the Embryogenesis of the Cuttlefish (Frontiers in physiology · 2020Article
- Evolutionary "Experiments" in Symbiosis: The Study of Model Animals Provides Insights into the Mechanisms Underlying the Diversity of Host-Microbe Interactions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2019Review
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
The symbiosis between the squid Euprymna scolopes and its luminous symbiont, Vibrio fischeri, is characterized by daily transcriptional rhythms in both partners and daily fluctuations in symbiont luminescence. In this study, we sought to determine whether symbionts affect host transcriptional rhythms. We identified two transcripts in host tissues (E. scolopes cry1 [escry1] and escry2) that encode cryptochromes, proteins that influence circadian rhythms in other systems. Both genes cycled daily in the head of the squid, with a pattern similar to that of other animals, in which expression of certain cry genes is entrained by environmental light. In contrast, escry1 expression cycled in the symbiont-colonized light organ with 8-fold upregulation coincident with the rhythms of bacterial luminescence, which are offset from the day/night light regime. Colonization of the juvenile light organ by symbionts was required for induction of escry1 cycling. Further, analysis with a mutant strain defective in light production showed that symbiont luminescence is essential for cycling of escry1; this defect could be complemented by presentation of exogenous blue light. However, blue-light exposure alone did not induce cycling in nonsymbiotic animals, but addition of molecules of the symbiont cell envelope to light-exposed animals did recover significant cycling activity, showing that light acts in synergy with other symbiont features to induce cycling. While symbiont luminescence may be a character specific to rhythms of the squid-vibrio association, resident microbial partners could similarly influence well-documented daily rhythms in other systems, such as the mammalian gut.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.