ReviewAnnals of biomedical engineering2013
Physical factors effecting cerebral aneurysm pathophysiology.
Review in Annals of biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 89 citations in OpenAlex.
- Chapter 1: The Natural History of Intracranial Aneurysms.Brain sciences · 2026Review
- Predictors of Outcome Clusters in Patients With Unruptured Intracranial Aneurysms Treated With Microsurgery: An Unsupervised Machine Learning Analysis.Neurosurgery practice · 2026Article
- From hemodynamic stress to inflammatory wall remodeling in intracranial aneurysms.Frontiers in molecular biosciences · 2026Review
- Biomimetic Glycosaminoglycan-Analog Hydrogel for Improved Embolization of Aneurysms: Environment-Selective Swelling.Advanced healthcare materials · 2025Article
- Cerebral Aneurysm: Filling the Gap Between Pathophysiology and Nanocarriers.International journal of molecular sciences · 2024Review
- Isolation and focal treatment of brain aneurysms using interfacial fluid trapping.Science advances · 2024Article
- Study the local metabolic changes of aneurysms through microcatheter sampling.Scientific reports · 2024Article
- The Management of Intracranial Aneurysms: Current Trends and Future Directions.Neurology international · 2024Review
- Risk factors and predictive indicators of rupture in cerebral aneurysms.Frontiers in physiology · 2024Review
- Morphology and Hemodynamics of Cerebral Arteries and Aneurysms in a Rare Pair of Monozygotic Twins.Diagnostics (Basel, Switzerland) · 2023Article
- A matched-pair case control study identifying hemodynamic predictors of cerebral aneurysm growth using computational fluid dynamics.Frontiers in physiology · 2023Article
- Effects of Pulsatile Flow Rate and Shunt Ratio in Bifurcated Distal Arteries on Hemodynamic Characteristics Involved in Two Patient-Specific Internal Carotid Artery Sidewall Aneurysms: A Numerical Study.Bioengineering (Basel, Switzerland) · 2022Article
- Characterizing Intracranial Hemodynamics in Sickle Cell Anemia: Impact of Patient-Specific Viscosity.Cardiovascular engineering and technology · 2022Article
- Single Center Retrospective Analysis of Cerebral Aneurysms from a Patient Sample Data Collection at a Comprehensive Stroke Center.Spartan medical research journal · 2022Article
- Biophysical targeting of high-risk cerebral aneurysms.Bioengineering & translational medicine · 2022Article
- Developing anFrontiers in physiology · 2022Article
- Towards Automatic Prediction of Outcome in Treatment of Cerebral Aneurysms.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2022Article
- MicroRNA-124-5p delays the progression of cerebral aneurysm by regulating FoxO1.Experimental and therapeutic medicine · 2021Article
- Effect of bifurcation in the hemodynamic changes and rupture risk of small intracranial aneurysm.Neurosurgical review · 2021Article
- Computational and experimental investigation of particulate matter deposition in cerebral side aneurysms.Journal of the Royal Society, Interface · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Many factors that are either blood-, wall-, or hemodynamics-borne have been associated with the initiation, growth, and rupture of intracranial aneurysms. The distribution of cerebral aneurysms around the bifurcations of the circle of Willis has provided the impetus for numerous studies trying to link hemodynamic factors (flow impingement, pressure, and/or wall shear stress) to aneurysm pathophysiology. The focus of this review is to provide a broad overview of such hemodynamic associations as well as the subsumed aspects of vascular anatomy and wall structure. Hemodynamic factors seem to be correlated to the distribution of aneurysms on the intracranial arterial tree and complex, slow flow patterns seem to be associated with aneurysm growth and rupture. However, both the prevalence of aneurysms in the general population and the incidence of ruptures in the aneurysm population are extremely low. This suggests that hemodynamic factors and purely mechanical explanations by themselves may serve as necessary, but never as necessary and sufficient conditions of this disease's causation. The ultimate cause is not yet known, but it is likely an additive or multiplicative effect of a handful of biochemical and biomechanical factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.