ArticleAnnals of biomedical engineering2013
Effect of age and exercise on the viscoelastic properties of rat tail tendon.
Article in Annals of biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Early-life exercise effects on Achilles tendon in mice selectively bred for high voluntary wheel-running behavior.Physiological reports · 2025Article
- Extracellular matrix dysregulation in aging, calcification, and cancer diseases: insights into cellular senescence, inflammation, and novel therapeutic strategies.International journal of biological sciences · 2025Review
- Effect of Aging on Tendon Biology, Biomechanics and Implications for Treatment Approaches.International journal of molecular sciences · 2023Review
- Guidelines for ex vivo mechanical testing of tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Review
- Modeling fatigue failure in soft tissue using a visco-hyperelastic model with discontinuous damage.Journal of the mechanical behavior of biomedical materials · 2023Article
- Understanding altered contractile properties in advanced age: insights from a systematic muscle modelling approach.Biomechanics and modeling in mechanobiology · 2023Article
- Impact of aging on tendon homeostasis, tendinopathy development, and impaired healing.Connective tissue research · 2023Review
- Increasing Vascular Response to Injury Improves Tendon Early Healing Outcome in Aged Rats.Annals of biomedical engineering · 2022Article
- The Influence of Different Modes of Exercise on Healthy and Injured Tendons.Stem cells international · 2022Review
- Skeletally immature patient showed lower graft maturity than skeletally mature patient after ACL reconstruction with a rounded rectangular femoral tunnel.Scientific reports · 2021Article
- Mechanical properties of the different rotator cuff tendons in the rat are similarly and adversely affected by age.Journal of biomechanics · 2021Article
- Relationship between mechanical properties (shear modulus and viscosity), age, and sex in uninjured Achilles tendons.Translational sports medicine · 2020Article
- The impact of loading, unloading, ageing and injury on the human tendon.The Journal of physiology · 2019Review
- A review of methods to measure tendon dimensions.Journal of orthopaedic surgery and research · 2019Review
- Biology of Tendon Stem Cells and Tendon in Aging.Frontiers in genetics · 2019Review
- Tendon Remodeling in Response to Resistance Training, Anabolic Androgenic Steroids and Aging.Cells · 2018Review
- Evaluation of transcatheter heart valve biomaterials: Biomechanical characterization of bovine and porcine pericardium.Journal of the mechanical behavior of biomedical materials · 2017Article
- Biology and mechano-response of tendon cells: Progress overview and perspectives.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Review
- C57BL/6 life span study: age-related declines in muscle power production and contractile velocity.Age (Dordrecht, Netherlands) · 2015Article
- Shear load transfer in high and low stress tendons.Journal of the mechanical behavior of biomedical materials · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Tendon mechanical properties are thought to degrade during aging but improve with exercise. A remaining question is whether exercise in aged animals provides sufficient regenerative, systemic stimulus to restore younger mechanical behaviors. Herein we address that question with tail tendons from aged and exercised rats, which would be subject to systemic effects but not direct loading from the exercise regimen. Twenty-four month old rats underwent one of three treadmill exercise training protocols for 12 months: sedentary (walking at 0° incline for 5 min/day), moderate (running at 0° incline for 30 min/day), or high (running at 4° incline for 30 min/day). A group of 9 month old rats were used to provide an adult control, while a group of 3 month old rats provided a young control. Tendons were harvested at sacrifice and mechanically tested. Results show significant age-dependent differences in modulus, ultimate stress, relaxation rate, and percent relaxation. Relaxation rate was strain-dependent, consistent with nonlinear superposition or Schapery models but not with quasilinear viscoelasticity (QLV). Trends in exercise data suggest that with exercise, tendons assume the elastic character of younger rats (lower elastic modulus and ultimate stress).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.