ArticleClinical cancer research : an official journal of the American Association for Cancer Research2013
Molecular pathways: environmental estrogens activate nongenomic signaling to developmentally reprogram the epigenome.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- A State of the Science Review of Human Health Effects of the Michigan Polybrominated Biphenyl Contamination after Five Decades.Environmental health perspectives · 2025Review
- The Influence of Environmental Exposure to Xenoestrogens on the Risk of Cancer Development.International journal of molecular sciences · 2024Review
- Herbal Treatment of Female Urogenital Atrophy: A Retrospective Cohort Analysis.Complementary medicine research · 2024Article
- Endocrine disrupting chemicals in the pathogenesis of hypospadias; developmental and toxicological perspectives.Current research in toxicology · 2021Review
- Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium.Biomolecules · 2019Review
- Endocrine disruption through membrane estrogen receptors and novel pathways leading to rapid toxicological and epigenetic effects.The Journal of steroid biochemistry and molecular biology · 2019Review
- Intergenerational effects of endocrine-disrupting compounds: a review of the Michigan polybrominated biphenyl registry.Epigenomics · 2018Review
- Epigenetic Programming of Synthesis, Release, and/or Receptor Expression of Common Mediators Participating in the Risk/Resilience for Comorbid Stress-Related Disorders and Coronary Artery Disease.International journal of molecular sciences · 2018Review
- GPER modulators: Opportunity Nox on the heels of a class Akt.The Journal of steroid biochemistry and molecular biology · 2018Review
- Cooperation of Genomic and Rapid Nongenomic Actions of Estrogens in Synaptic Plasticity.Molecular neurobiology · 2017Review
- Estrogens in Male Physiology.Physiological reviews · 2017Review
- Membrane estrogen receptor 1 is required for normal reproduction in male and female mice.Journal of endocrinology and reproduction : JER · 2017Article
- Environmental factors, epigenetics, and developmental origin of reproductive disorders.Reproductive toxicology (Elmsford, N.Y.) · 2017Review
- Morphologic and molecular changes in the placenta: what we can learn from environmental exposures.Fertility and sterility · 2016Review
- Endocrine-disrupting chemicals and uterine fibroids.Fertility and sterility · 2016Review
- Methoxychlor and Vinclozolin Induce Rapid Changes in Intercellular and Intracellular Signaling in Liver Progenitor Cells.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Minireview: Epigenomic Plasticity and Vulnerability to EDC Exposures.Molecular endocrinology (Baltimore, Md.) · 2016Review
- Reprogramming of the Epigenome by MLL1 Links Early-Life Environmental Exposures to Prostate Cancer Risk.Molecular endocrinology (Baltimore, Md.) · 2016Article
- Membrane-Localized Estrogen Receptor 1 Is Required for Normal Male Reproductive Development and Function in Mice.Endocrinology · 2016Article
- Multigenerational and transgenerational effects of endocrine disrupting chemicals: A role for altered epigenetic regulation?Seminars in cell & developmental biology · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Exposure to environmental xenoestrogens is a major health concern because of the ability of these compounds to perturb estrogen receptor (ER) signaling and act as endocrine disrupting compounds (EDC). Inappropriate exposure to EDCs during development, even at low doses, can predispose individuals to an increased lifetime risk of disease, including cancer. Recent data indicate that perinatal exposure to EDCs increases cancer risk by (re)programming the epigenome via alterations in DNA and histone methylation. We and others have begun to dissect the mechanisms by which xenoestrogens disrupt the epigenetic machinery to reprogram the epigenome and induce developmental reprogramming. Our studies revealed that xenoestrogens induce nongenomic ER signaling to activate PI3K/AKT, resulting in AKT phosphorylation and inactivation of the histone methyltransferase EZH2, thus providing a direct link to disruption of the epigenome. Other epigenetic "readers, writers, and erasers" may also be targeted by nongenomic signaling, suggesting this is a central mechanism by which xenoestrogens and other EDCs disrupt the epigenome to induce developmental reprogramming. Elucidating mechanisms of developmental reprogramming of the epigenome is important for understanding how environmental exposures increase cancer risk, and provides a rationale for developing epigenetic interventions that can reverse the effects of environmental exposures to reduce cancer risk.
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