ArticleImmunogenetics2013
Current perspectives on the intensity of natural selection of MHC loci.
Article in Immunogenetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 35 citations in OpenAlex.
- Early human migration determines the risk of being attacked by wolves: ethnic gene diversity on the development of systemic lupus erythematosus.Journal of rheumatic diseases · 2024Review
- Spatial and temporal diversity of positive selection on shared haplotypes at the PSCA locus among worldwide human populations.Heredity · 2023Article
- Joint estimation of selection intensity and mutation rate under balancing selection with applications to HLA.Genetics · 2022Article
- Challenging Ancient DNA Results About Putative HLA Protection or Susceptibility to Yersinia pestis.Molecular biology and evolution · 2022Article
- Expression quantitative trait loci of genes predicting outcome are associated with survival of multiple myeloma patients.International journal of cancer · 2021Article
- Shared Signature of Recent Positive Selection on the TSBP1-BTNL2-HLA-DRA Genes in Five Native Populations from North Borneo.Genome biology and evolution · 2020Article
- Population-Specific Genetic and Expression Differentiation in Europeans.Genome biology and evolution · 2020Article
- Inter- and intrabreed diversity of the major histocompatibility complex (MHC) in primitive and draft horse breeds.PloS one · 2020Article
- Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Facial masculinity does not appear to be a condition-dependent male ornament and does not reflect MHC heterozygosity in humans.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations.PLoS biology · 2019Article
- Elucidating the origin of HLA-B*73 allelic lineage: Did modern humans benefit by archaic introgression?Immunogenetics · 2017Article
- Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection.Molecular biology and evolution · 2016Article
- Patterns of MHC-DRB1 polymorphism in a post-glacial island canid, the Newfoundland red fox (Vulpes vulpes deletrix), suggest balancing selection at species and population timescales.Immunogenetics · 2016Article
- Computer simulation of human leukocyte antigen genes supports two main routes of colonization by human populations in East Asia.BMC evolutionary biology · 2015Article
- A human-specific allelic group of the MHC DRB1 gene in primates.Journal of physiological anthropology · 2014Article
- The relevance of HLA sequencing in population genetics studies.Journal of immunology research · 2014Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polymorphism of genes in the major histocompatibility complex (MHC) is believed to be maintained by balancing selection. However, direct evidence of selection has proven difficult to demonstrate. In 1994, Satta and colleagues estimated the selection intensity of the human MHC (human leukocyte antigen (HLA)) loci; however, at that time the number of HLA sequences was limited. By comparing five different methods, this study demonstrated the best way to calculate the selection coefficient, through a computer simulation study. Since the study, many HLA nucleotide sequences have been made available. Our new analysis takes advantage of these newly available sequences and compares new estimates with those of the previous study. Generally, our new results are consistent with those of the 1994 study. Our results show that, even after 20 years of exhaustive sequencing of human HLA, the number of dominant HLA alleles, on which our original estimate of selection intensity depended, appears to be conserved. Indeed, according to the frequency distribution for each HLA allele, most sequences in the database were minor or private alleles; therefore, we conclude that the selection intensities of HLA loci are at most 4.4 % even though the HLA is the prominent example on which the natural selection has been operating.
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