ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2013
Clustering of antimicrobial resistance outbreaks across bacterial species in the intensive care unit.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Model-based methods for hospital infection prevention and control: potential and challenges.BMC global and public health · 2025Article
- Comparing automated surveillance systems for detection of pathogen-related clusters in healthcare settings.Antimicrobial resistance and infection control · 2024Article
- Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units.Genome medicine · 2021Article
- Adverse Events and Healthcare Utilization Associated With Outpatient Parenteral Antimicrobial Therapy Among Older Versus Younger Adults.Open forum infectious diseases · 2020Article
- Automated detection of outbreaks of antimicrobial-resistant bacteria in Japan.The Journal of hospital infection · 2019Article
- Use of WHONET-SaTScan system for simulated real-time detection of antimicrobial resistance clusters in a hospital in Italy, 2012 to 2014.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2017Article
- Multiple drug resistant organisms in healthcare: the failure of contact precautions.Journal of infection prevention · 2015Article
- Colonization with Multi-Drug Resistant Organisms in Nursing Homes: Scope, Importance, and Management.Current geriatrics reports · 2015Article
- Outbreak Column 15: Carbapenemase-producing Enterobacteriaceae.Journal of infection prevention · 2014Article
- Journal roundup.The Journal of hospital infection · 2014Article
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6 authors.
Funding
Abstract
backgroundThere are frequent reports of intensive care unit (ICU) outbreaks due to transmission of particular antibiotic-resistant bacteria. Less is known about the burden of outbreaks of resistance due to horizontal transfer of mobile genetic elements between species. Moreover, the potential of existing statistical software as a preliminary means for detecting such events has never been assessed. This study uses a software package to determine the burden of species and resistance outbreaks in 2 adjacent ICUs and to look for evidence of clustering of resistance outbreaks consistent with interspecies transmission of resistance elements.
methodsA retrospective analysis of data from 2 adjacent 15-bed adult ICUs between 2002 and 2009 was undertaken. Detection of bacterial species-groups and resistance outbreaks was conducted using SaTScan and WHONet-SaTScan software. Resampling and permutation methods were applied to investigate temporal clustering of outbreaks.
resultsOutbreaks occurred for 69% of bacterial species-groups (18/26), and resistance outbreaks were detected against 63% of antibiotics (10/16). Resistance outbreaks against 7 of 10 antibiotics were observed in multiple species-groups simultaneously and there was evidence of inter-species-group dependence for 4 of 7 antibiotics; background temporal changes in resistance did not explain the temporal aggregation of outbreaks in 3 of 7 antibiotics.
conclusionsSpecies outbreaks occurred for the majority of bacteria commonly identified in the ICU. There was evidence for frequent temporal clustering of resistance outbreaks consistent with interspecies transmission of resistance elements. Wider application of outbreak detection software combined with targeted sequencing of bacterial genomes is needed to understand the contribution of interspecies gene transfer to resistance emergence.
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