ArticleMolecular systems biology2013
Construction of human activity-based phosphorylation networks.
Article in Molecular systems biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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Who cites it
95 citing papers in PubMed, 162 citations in OpenAlex.
- NEK Family Kinases: Structure, Function, and Role in Disease.Biomolecules · 2025Review
- Predisposing deleterious variants in the cancer-associated human kinases in the global populations.PloS one · 2024Article
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- Pharmacological approaches to understanding protein kinase signaling networks.Frontiers in pharmacology · 2023Review
- Uncovering common pathobiological processes between COVID-19 and pulmonary arterial hypertension by integrating Omics data.Pulmonary circulation · 2023Article
- Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis.Life science alliance · 2022Article
- Shining Light on Protein Kinase Biomarkers with Fluorescent Peptide Biosensors.Life (Basel, Switzerland) · 2022Review
- A human kinase yeast array for the identification of kinases modulating phosphorylation-dependent protein-protein interactions.Molecular systems biology · 2022Article
- Proteome-Wide Characterizations ofAnalytical chemistry · 2021Article
- Network module-based drug repositioning for pulmonary arterial hypertension.CPT: pharmacometrics & systems pharmacology · 2021Article
- KEA3: improved kinase enrichment analysis via data integration.Nucleic acids research · 2021Article
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- MARK2 phosphorylates eIF2α in response to proteotoxic stress.PLoS biology · 2021Article
- Gene co-expression in the interactome: moving from correlation toward causation via an integrated approach to disease module discovery.NPJ systems biology and applications · 2021Article
- Pharmacological and phosphoproteomic approaches to roles of protein kinase C in kappa opioid receptor-mediated effects in mice.Neuropharmacology · 2020Article
- Network determinants of cardiovascular calcification and repositioned drug treatments.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Developments and Applications of Functional Protein Microarrays.Molecular & cellular proteomics : MCP · 2020Review
- Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites.Nature communications · 2020Article
- Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome.Nature communications · 2020Article
- Mass Spectrometry-Based Discovery ofMass spectrometry (Tokyo, Japan) · 2020Article
35 more citing papers are in PubMed but not listed here.
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Authors and funding
34 authors at 13 institutions in 4 countries.
Funding
Abstract
The landscape of human phosphorylation networks has not been systematically explored, representing vast, unchartered territories within cellular signaling networks. Although a large number of in vivo phosphorylated residues have been identified by mass spectrometry (MS)-based approaches, assigning the upstream kinases to these residues requires biochemical analysis of kinase-substrate relationships (KSRs). Here, we developed a new strategy, called CEASAR, based on functional protein microarrays and bioinformatics to experimentally identify substrates for 289 unique kinases, resulting in 3656 high-quality KSRs. We then generated consensus phosphorylation motifs for each of the kinases and integrated this information, along with information about in vivo phosphorylation sites determined by MS, to construct a high-resolution map of phosphorylation networks that connects 230 kinases to 2591 in vivo phosphorylation sites in 652 substrates. The value of this data set is demonstrated through the discovery of a new role for PKA downstream of Btk (Bruton's tyrosine kinase) during B-cell receptor signaling. Overall, these studies provide global insights into kinase-mediated signaling pathways and promise to advance our understanding of cellular signaling processes in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.