ReviewGut microbes
Customizing laboratory mice by modifying gut microbiota and host immunity in an early "window of opportunity".
Review in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Association of fermented dairy consumption with asthma and wheeze risk in children: a systematic review and meta-analysis of observational studies.Frontiers in nutrition · 2026Pooled it
- Neonatal microbiome dysbiosis decoded by mNGS: from mechanistic insights to precision interventions.Frontiers in cellular and infection microbiology · 2025Review
- Gut microbiota-driven brain Aβ amyloidosis in mice requires microglia.The Journal of experimental medicine · 2022Article
- Health Monitoring of Laboratory Rodent Colonies-Talking about (R)evolution.Animals : an open access journal from MDPI · 2021Review
- An Oligosaccharide Rich Diet IncreasesFrontiers in microbiology · 2021Article
- Experimental evaluation of the importance of colonization history in early-life gut microbiota assembly.eLife · 2018Article
- Changes in Gut Microbiota Prior to Influenza A Virus Infection Do Not Affect Immune Responses in Pups or Juvenile Mice.Frontiers in cellular and infection microbiology · 2018Article
- Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPScientific reports · 2017Article
- Article
- Early-Life Host-Microbiome Interphase: The Key Frontier for Immune Development.Frontiers in pediatrics · 2017Review
- Links Between the Microbiome and Bone.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Review
- Approaches for analyzing the roles of mast cells and their proteases in vivo.Advances in immunology · 2015Review
- Impact of the gut microbiota on rodent models of human disease.World journal of gastroenterology · 2014Review
- Growth and metastasis of B16-F10 melanoma cells is not critically dependent on host CD73 expression in mice.BMC cancer · 2014Article
- 'As above, so below' examining the interplay between emotion and the immune system.Immunology · 2014Review
- Transfer of gut microbiota from lean and obese mice to antibiotic-treated mice.Scientific reports · 2014Article
- Prokaryotes Versus Eukaryotes: Who is Hosting Whom?Frontiers in veterinary science · 2014Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently investigated how post-natal microbial gut colonization is important for the development of the immune system, especially in the systemic compartments. This addendum presents additional data which in accordance with our previous findings show that early life microbial colonization is critical for a fine-tuned immune homeostasis to develop also in the intestinal environment. A generalized reduction in the expression of immune signaling related genes in the small intestine may explain previously shown increased systemic adaptive immune reactivity, if the regulatory cross-talk between intra- and extra-intestinal immune cells is immature following a neonatal germ-free period. These findings are furthermore discussed in the context of recently published results on how lack of microbial exposure in the neonatal life modifies disease expression in rodents used as models mimicking human inflammatory diseases. In particular, with a focus on how these interesting findings could be used to optimize the use of rodent models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.