Evidence map›Paper›PMID 23549432›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2013

Childhood body mass index and multiple sclerosis risk: a long-term cohort study.

Kassandra L Munger, Joan Bentzen, Bjarne Laursen, Egon Stenager, Nils Koch-Henriksen, Thorkild I A Sørensen, Jennifer L Baker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 6 pooled it
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 6 syntheses or guidelines pooled it, 296 citations in OpenAlex.

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60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Kassandra L MungerDepartment of Nutrition, Harvard School of Public Health, USA. kgorham@hsph.harvard.edu
Joan Bentzen
Bjarne Laursen
Egon Stenager
Nils Koch-Henriksen
Thorkild I A Sørensen
Jennifer L Baker
University of Southern Denmark · DKAarhus University Hospital · DKCopenhagen University Hospital · DKDanish Multiple Sclerosis Center · DKHarvard University · USUniversity of Copenhagen · DK

Funding

Prospective Study of Vitamin D and Multiple SclerosisR01NS046635 · NINDS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ASCHERIO, ALBERTO · 2004 to 2012
$3.0M
NINDS NIH HHS NS046635NINDS NIH HHS R01 NS046635
6 · The paper itself

Abstract

backgroundObesity in late adolescence has been associated with an increased risk of multiple sclerosis (MS); however, it is not known if body size in childhood is associated with MS risk.

methodsUsing a prospective design we examined whether body mass index (BMI) at ages 7-13 years was associated with MS risk among 302,043 individuals in the Copenhagen School Health Records Register (CSHRR). Linking the CSHRR with the Danish MS registry yielded 774 MS cases (501 girls, 273 boys). We used Cox proportional hazards models to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs).

resultsAmong girls, at each age 7-13 years, a one-unit increase in BMI z-score was associated with an increased risk of MS (HR(age 7)=1.20, 95% CI: 1.10-1.30; HR(age 13)=1.18, 95% CI: 1.08-1.28). Girls who were ≥95(th) percentile for BMI had a 1.61-1.95-fold increased risk of MS as compared to girls <85(th) percentile. The associations were attenuated in boys. The pooled HR for a one-unit increase in BMI z-score at age 7 years was 1.17 (95% CI: 1.09-1.26) and at age 13 years was 1.15 (95% CI: 1.07-1.24).

conclusionHaving a high BMI in early life is a risk factor for MS, but the mechanisms underlying the association remain to be elucidated.

Indexed as

Body Mass IndexAdolescentChildCohort StudiesFemaleHumansMaleMultiple SclerosisObesityRisk Factorscohort studiesMultiple sclerosisobesityrisk factors in epidemiology

Identifiers

PMID23549432
PMCPMC4418015
OpenAlexW2165184392

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.