Evidence map›Paper›PMID 23549386›Full record

ReviewViruses2013

Interpreting the Epstein-Barr Virus (EBV) epigenome using high-throughput data.

Aaron Arvey, Italo Tempera, Paul M Lieberman

Abstract readReview
In one paragraph

Review in Viruses, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Chromatin Control of EBV Infection and Latency.Current topics in microbiology and immunology · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Epigenetic lifestyle of Epstein-Barr virus.Seminars in immunopathology · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aaron ArveyMemorial Sloan Kettering Cancer Center, NY, USA. aarvey@cbio.mskcc.org
Italo Tempera
Paul M Lieberman

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Alessandro Gardini · 1985 to 2026
$75.9M
Regulation of Epstein-Barr Virus LatencyR01CA093606 · NCI · WISTAR INSTITUTE · PI LIEBERMAN, PAUL M. · 2002 to 2022
$6.7M
Epigenetic Regulation of Epstein-Barr Virus Latency ProgramsR01DE017336 · NIDCR · WISTAR INSTITUTE · PI PAUL M. LIEBERMAN · 2005 to 2026
$6.5M
Regulation of EBV reactivationR01CA085678 · NCI · WISTAR INSTITUTE · PI LIEBERMAN, PAUL M. · 2001 to 2011
$2.7M
Regulation of EBV Latency by Chromosome ConformationK99AI099153 · NIAID · WISTAR INSTITUTE · PI TEMPERA, ITALO · 2012 to 2012
$109k
NCI NIH HHS CA085678NCI NIH HHS CA093606NCI NIH HHS P30 CA010815NCI NIH HHS P30CA10815NCI NIH HHS R01 CA085678NCI NIH HHS R01 CA093606NIAID NIH HHS K99 AI099153NIAID NIH HHS K99AI099153NIDCR NIH HHS DE017336NIDCR NIH HHS R01 DE017336
6 · The paper itself

Abstract

The Epstein-Barr virus (EBV) double-stranded DNA genome is subject to extensive epigenetic regulation. Large consortiums and individual labs have generated a vast number of genome-wide data sets on human lymphoblastoid and other cell lines latently infected with EBV. Analysis of these data sets reveals important new information on the properties of the host and viral chromosome structure organization and epigenetic modifications. We discuss the mapping of these data sets and the subsequent insights into the chromatin structure and transcription factor binding patterns on latent EBV genomes. Colocalization of multiple histone modifications and transcription factors at regulatory loci are considered in the context of the biology and regulation of EBV.

Indexed as

Epigenesis, GeneticEpigenomicsGenome, ViralHerpesvirus 4, HumanHumans

Identifiers

PMID23549386
PMCPMC3705264

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.