ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2013
Critical pertussis illness in children: a multicenter prospective cohort study.
Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 5 of them syntheses that pooled it.
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Who cites it
67 citing papers in PubMed, 5 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Influencing factors for severe pertussis among Chinese children: A meta-analysis.Human vaccines & immunotherapeutics · 2026Pooled it
- Variability in the Diagnostic Criteria for Severe Pertussis: A Systematic Review.JAMA network open · 2026Pooled it
- Pertussis infection in critically ill infants: meta-analysis and validation of a mortality score.Critical care (London, England) · 2025Pooled it
- Burden of pertussis in infants in the Eastern Mediterranean Region and the impact of maternal vaccination: a systematic review.BMC public health · 2025Pooled it
- SEVERE PERTUSSIS IN CHILDHOOD: UPDATE AND CONTROVERSY - SYSTEMATIC REVIEW.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2019Pooled it
- Expert consensus on competency enhancement of pertussis prevention, diagnosis, and management for healthcare professionals through medical-preventive integration.Infectious diseases & immunity · 2026Article
- Cerebral venous thrombosis in infant with pertussis: A rare complication in a hyperleukocytosis and thrombocytosis Storm, A threshold worth defining.Hematology, transfusion and cell therapy · 2026Article
- Clinical characteristics and risk factors for severe pertussis in infants aged less than 3 months.Translational pediatrics · 2026Article
- Mechanisms of Pertussis Toxin Action: ADP-Ribosylation and Its Role in Pertussis Pathogenesis.Toxins · 2026Review
- Risk factors for mortality in children with pertussis and hyperleukocytosis undergoing exchange transfusion: a single-center retrospective cohort study.Italian journal of pediatrics · 2026Article
- Hypercapnia as a Key Mechanism in the Development of Pulmonary Hypertension in Malignant Pertussis: A Case Report.Respirology case reports · 2026Article
- Practice variability in the management of critical pertussis: a multicenter survey of pediatric intensivists in the Arabian Gulf Cooperation Council region.Frontiers in pediatrics · 2026Article
- Early Exchange Transfusion in Critical Pertussis: A Case Report Supporting Timely Intervention.Case reports in pediatrics · 2026Article
- Economic evaluation of the second booster dose of diphtheria-tetanus-acellular pertussis vaccine for children aged 6 years in Zhejiang Province: A cost-utility analysis.Human vaccines & immunotherapeutics · 2025Article
- Retrospective analysis of 104 cases of pediatric severe pertussis in Southern China.BMC infectious diseases · 2025Article
- Severe pertussis complicated by pulmonary hypertension in a Moroccan infant: a case report.Journal of medical case reports · 2025Article
- Impact of pertussis vaccination on PT-IgG levels and clinical characteristics in 3-12-month-old infants with acute pertussis.European journal of pediatrics · 2025Article
- The clinical analysis and indications for exchange transfusion in 158 children with pertussis characterized by marked leukocytosis.Italian journal of pediatrics · 2025Article
- Article
- Risk factors and mortality in children with severe pertussis: the role of exchange transfusion in a PICU.Italian journal of pediatrics · 2025Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
22 authors at 3 institutions in 1 country.
Funding
Abstract
objectivePertussis persists in the United States despite high immunization rates. This report characterizes the presentation and acute course of critical pertussis by quantifying demographic data, laboratory findings, clinical complications, and critical care therapies among children requiring admission to the PICU.
designProspective cohort study.
settingEight PICUs comprising the Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network and 17 additional PICUs across the United States. PATIENTS: Eligible patients had laboratory confirmation of pertussis infection, were younger than 18 years old, and died in the PICU or were admitted to the PICU for at least 24 hours between June 2008 and August 2011.
interventionsNone. MEASUREMENTS AND MAIN
resultsA total of 127 patients were identified. Median age was 49 days, and 105 (83%) patients were less than 3 months old. Fifty-five (43%) patients required mechanical ventilation and 12 patients (9.4%) died during initial hospitalization. Pulmonary hypertension was found in 16 patients (12.5%) and was present in 75% of patients who died, compared with 6% of survivors (p < 0.001). Median WBC was significantly higher in those requiring mechanical ventilation (p < 0.001), those with pulmonary hypertension (p < 0.001), and nonsurvivors (p < 0.001). Age, sex, and immunization status did not differ between survivors and nonsurvivors. Fourteen patients received leukoreduction therapy (exchange transfusion [12], leukopheresis [1], or both [1]). Survival benefit was not apparent.
conclusionsPulmonary hypertension may be associated with mortality in pertussis critical illness. Elevated WBC is associated with the need for mechanical ventilation, pulmonary hypertension, and mortality risk. Research is indicated to elucidate how pulmonary hypertension, immune responsiveness, and elevated WBC contribute to morbidity and mortality and whether leukoreduction might be efficacious.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.