ArticleBMC complementary and alternative medicine2013
Dracaena arborea alleviates ultra-structural spermatogenic alterations in streptozotocin-induced diabetic rats.
Article in BMC complementary and alternative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 37 citations in OpenAlex.
- Effect of saponin on spermatogenesis and testicular structure in streptozotocin-induced diabetic mice.Veterinary research forum : an international quarterly journal · 2023Article
- Phytomedicinal therapeutics for male infertility: critical insights and scientific updates.Journal of natural medicines · 2022Review
- Dracaena arborea improves sperm characteristics and antioxidant enzymes in adult male rats with experimental varicocele.JBRA assisted reproduction · 2021Article
- Cytoarchitectural improvement in Leydig cells of diabetic rats after treatment with aqueous and ethanol extracts ofJournal of traditional and complementary medicine · 2021Article
- Article
- The effects of sacubitril/valsartan and ramipril on the male fertility in hypertensive rats.Northern clinics of Istanbul · 2020Article
- Gliclazide alone or in combination with atorvastatin ameliorated reproductive damage in streptozotocin-induced type 2 diabetic male rats.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Article
- Troxerutin affects the male fertility in prepubertal type 1 diabetic male rats.Iranian journal of basic medical sciences · 2019Article
- Modulation of diabetes-mellitus-induced male reproductive dysfunctions in experimental animal models with medicinal plants.Pharmacognosy reviews · 2014Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundInfertility is a common complication in diabetic men and experimental animals, mainly due to loss of germ cells by apoptotic cell death. The aim of this study was to evaluate the effects of aqueous and ethanol extracts of Dracaena arborea in streptozotocin-induced ultra-structural spermatogenic alterations in Wistar rats.
methodsDiabetic animals were orally treated with Millipore water (10 ml/kg), sildenafil citrate (1.44 mg/kg) or Dracaena arborea aqueous (500 mg/kg) and ethanol (100 mg/kg) extracts for three weeks. A group of non diabetic rats received Millipore water (10 ml/kg) and served as healthy control group. Blood glucose was monitored at the beginning and the end of the study. One day after the last treatment, animals were sacrificed and the testes immediately removed were morphologically observed and prepared for electron microscopy analysis of spermatogenesis.
resultsOur results showed that Dracaena arborea was devoid of any anti-hyperglycemic activity. In the untreated diabetic rats, hyperglycemia severely damaged the testes morphology as well as the spermatogenic process as evidenced by the: thickness of basement membrane of the seminiferous tubule; mitochondria alteration; abnormal spermatocyte cells displaying polymorphous nuclei, cytoplasmic vacuolization and necrosis; and disorganization and degeneration of sperm germ cells. Administration of sildenafil citrate and Dracaena arborea extracts to the diabetic rats improved testes morphology and reversed, although not completely, the impairment of spermatogenesis; this alleviating effect was more pronounced in animals treated with the aqueous extract (500 mg/kg) of Dracaena arborea.
conclusionDracaena arborea improves testes morphology and restores spermatogenesis in type 1 diabetic rats, without having major anti-hyperglycemic properties. These effects could be attributed to saponins, flavonoids, phenols and sterols revealed in this plant, which could be a useful component in the treatment of diabetes-induced testicular dysfunction.
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