ArticleBMC genomics2013
Species and condition specific adaptation of the transcriptional landscapes in Candida albicans and Candida dubliniensis.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 28 citations in OpenAlex.
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- White-to-opaque switching is involved in the phospholipase B production of Candida dubliniensis on Price's egg yolk agar.Odontology · 2019Article
- Stable Redox-Cycling Nitroxide Tempol Has Antifungal and Immune-Modulatory Properties.Frontiers in microbiology · 2019Article
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- Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion.PloS one · 2017Article
- Transcriptional landscape of trans-kingdom communication between Candida albicans and Streptococcus gordonii.Molecular oral microbiology · 2016Article
- A Genome-Wide Transcriptional Analysis of Yeast-Hyphal Transition in Candida tropicalis by RNA-Seq.PloS one · 2016Article
- Candida albicans exhibits enhanced alkaline and temperature induction of Efg1-regulated transcripts relative to Candida dubliniensis.Genomics data · 2015Article
- Defining the transcriptomic landscape of Candida glabrata by RNA-Seq.Nucleic acids research · 2015Article
- Advanced Applications of RNA Sequencing and Challenges.Bioinformatics and biology insights · 2015Review
- The Candida pathogenic species complex.Cold Spring Harbor perspectives in medicine · 2014Review
- The Rbf1, Hfl1 and Dbp4 of Candida albicans regulate common as well as transcription factor-specific mitochondrial and other cell activities.BMC genomics · 2014Article
- Emerging and emerged pathogenic Candida species: beyond the Candida albicans paradigm.PLoS pathogens · 2013Review
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough Candida albicans and Candida dubliniensis are most closely related, both species behave significantly different with respect to morphogenesis and virulence. In order to gain further insight into the divergent routes for morphogenetic adaptation in both species, we investigated qualitative along with quantitative differences in the transcriptomes of both organisms by cDNA deep sequencing.
resultsFollowing genome-associated assembly of sequence reads we were able to generate experimentally verified databases containing 6016 and 5972 genes for C. albicans and C. dubliniensis, respectively. About 95% of the transcriptionally active regions (TARs) contain open reading frames while the remaining TARs most likely represent non-coding RNAs. Comparison of our annotations with publically available gene models for C. albicans and C. dubliniensis confirmed approximately 95% of already predicted genes, but also revealed so far unknown novel TARs in both species. Qualitative cross-species analysis of these databases revealed in addition to 5802 orthologs also 399 and 49 species-specific protein coding genes for C. albicans and C. dubliniensis, respectively. Furthermore, quantitative transcriptional profiling using RNA-Seq revealed significant differences in the expression of orthologs across both species. We defined a core subset of 84 hyphal-specific genes required for both species, as well as a set of 42 genes that seem to be specifically induced during hyphal morphogenesis in C. albicans.
conclusionsSpecies-specific adaptation in C. albicans and C. dubliniensis is governed by individual genetic repertoires but also by altered regulation of conserved orthologs on the transcriptional level.
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