Evidence map›Paper›PMID 23547820›Full record

ArticleBiomarkers in medicine2013

Newborn screening for autism: in search of candidate biomarkers.

Gerald J Mizejewski, Barbara Lindau-Shepard, Kenneth A Pass

Abstract read
In one paragraph

Article in Biomarkers in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Porphyrinuria in Autism Spectrum Disorder: A Review.Current medicinal chemistry · 2024
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Immune activity at birth and later psychopathology in childhood.Brain, behavior, & immunity - health · 2020
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Biomarkers in autism.Frontiers in psychiatry · 2014
    Review
  15. Activity-Regulated Cytoskeleton-Associated Protein Dysfunction May Contribute to Memory Disorder and Earlier Detection of Autism Spectrum Disorders.Medical principles and practice : international journal of the Kuwait University, Health Science Centre
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gerald J MizejewskiDivision of Translational Medicine, Wadsworth Center, NYS Department of Health, PO Box 509, Albany, NY 12201 0509, USA. mizejew@wadsworth.org
Barbara Lindau-Shepard
Kenneth A Pass

Funding

NICHD NIH HHS N01 DK063430NIDDK NIH HHS N01-DK-6-3430
6 · The paper itself

Abstract

backgroundAutism spectrum disorder (ASD) represents a wide range of neurodevelopmental disorders characterized by impairments in social interaction, language, communication and range of interests. Autism is usually diagnosed in children 3-5 years of age using behavioral characteristics; thus, diagnosis shortly after birth would be beneficial for early initiation of treatment.

aimThis retrospective study sought to identify newborns at risk for ASD utilizing bloodspot specimens in an immunoassay. MATERIALS &

methodsThe present study utilized stored frozen specimens from ASD children already diagnosed at 15-36 months of age. The newborn specimens and controls were analyzed by immunoassay in a multiplex system that included 90 serum biomarkers and subjected to statisical analysis.

resultsThree sets of five biomarkers associated with ASD were found that differed from control groups. The 15 candidate biomarkers were then discussed regarding their association with ASD.

conclusionThis study determined that a statistically selected panel of 15 biomarkers successfully discriminated presumptive newborns at risk for ASD from those of nonaffected controls.

Indexed as

Neonatal ScreeningAutistic DisorderBiomarkersCase-Control StudiesChild, PreschoolFemaleHumansImmunoassayInfant, NewbornMaleRetrospective StudiesBiomarkers

Identifiers

PMID23547820
PMCPMC4981185

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.