ArticleSouth African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde2013
Gastric adenocarcinoma in Zambia: a case-control study of HIV, lifestyle risk factors, and biomarkers of pathogenesis.
Article in South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Associations Between Gastric Cancer Risk and Virus Infection Other Than Epstein-Barr Virus: A Systematic Review and Meta-analysis Based on Epidemiological Studies.Clinical and translational gastroenterology · 2020Pooled it
- Short term micronutrient-antioxidant supplementation has no impact on a serological marker of gastric atrophy in Zambian adults: retrospective analysis of a randomised controlled trial.BMC gastroenterology · 2014Trial
- Use of free blood in the stomach to diagnose gastric mucosal lesions prior to endoscopy: the Sanguis-filum.BMC research notes · 2026Article
- Histopathological subtypes and topographical subsites of gastric cancer in Sub-Saharan Africa: a scoping review.BMC cancer · 2026Article
- Prevalence of gastric cancer and its associated mortality among patients undergoing upper gastrointestinal endoscopy at a tertiary level hospital in Tanzania.BMC gastroenterology · 2025Article
- Fasting Gastric Juice Melatonin Levels in Relation to Gastroduodenal Pathologies Among Zambian Patients: A Cross Sectional Study.Health science reports · 2025Article
- Primary Tumors of the Brain and Central Nervous System in Adults and Children in Sub-Saharan Africa: Protocol for a Scoping Review.JMIR research protocols · 2025Article
- Mapping the cancer research landscape across Zambia: evidence to support national cancer control planning.Ecancermedicalscience · 2025Review
- Endoscopic diagnosis of gastric and oesophageal cancer in Lusaka, Zambia: a retrospective analysis.BMC gastroenterology · 2024Article
- Analysis of the proportion of university teaching hospital gastric cancer data included in the Zambia national cancer registry.African health sciences · 2023Article
- Introducing the Sanguis-Filum for Detection of Gastric Mucosal Lesions Prior to Endoscopy: A Study Protocol.Diagnostics (Basel, Switzerland) · 2022Article
- Serum antibodies to selectedMalawi medical journal : the journal of Medical Association of Malawi · 2022Article
- Evaluation of the association between gastric cancer and plasma selenium in Zambian adults: a case-control study.Ecancermedicalscience · 2022Article
- Associations between hepatitis B virus exposure and the risk of extrahepatic digestive system cancers: A hospital-based, case-control study (SIGES).Cancer medicine · 2021Article
- Molecular profiling of gastric cancer in a population with high HIV prevalence reveals a shift to MLH1 loss but not the EBV subtype.Cancer medicine · 2020Article
- Biomass Smoke Exposure Is Associated With Gastric Cancer and Probably Mediated Via Oxidative Stress and DNA Damage: A Case-Control Study.JCO global oncology · 2020Article
- Cancer Mortality Patterns in Tanzania: A Retrospective Hospital-Based Study, 2006-2015.JCO global oncology · 2020Article
- HIV related hypochlorhydria does not appear to respond to anti-retroviral therapy in Zambian adults: a case control study.The Pan African medical journal · 2018Article
- Serological response to Epstein-Barr virus early antigen is associated with gastric cancer and human immunodeficiency virus infection in Zambian adults: a case-control study.The Pan African medical journal · 2016Article
- Trends in upper gastrointestinal diagnosis over four decades in Lusaka, Zambia: a retrospective analysis of endoscopic findings.BMC gastroenterology · 2015Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundGastric cancer is a leading cause of cancer deaths worldwide but there are few data from Africa. We recently observed a trend towards diagnosis in younger patients.
objectiveTo test the hypothesis that HIV might have altered risk factors for acquisition of gastric cancer, in a case-control study in the University Teaching Hospital, Lusaka, Zambia.
methodsPatients (n=52) with confirmed gastric adenocarcinoma and controls (n=94) undergoing endoscopy but with no macroscopic gastric pathology. Established risk factors and HIV status were compared.
resultsHIV status did not differ significantly between cases and controls (odds ratio 1.03; 95% CI 0.2 - 4.3; p=1.00) and seroprevalence in cases was similar to that of the Zambian population. Smoking, regular alcohol intake, and gastric atrophy were all associated with cancer in univariate and multivariate analysis. Helicobacter pylori serology was positive in 84% of patients studied and cagA serology in 66%; neither serological marker was associated with cancer. Atrophy was common in cases (57%) and controls (30%) and associated with both smoking and alcohol use. Intestinal metaplasia was present in 17% of the controls, but was not associated with atrophy.
conclusionsHIV was not associated with gastric cancer and does not explain the apparent younger age distribution. Atrophy was common and was not essential for the development of intestinal metaplasia, suggesting that gastric carcinogenesis in Africa does not always follow the pathway from atrophy to intestinal metaplasia to gastric carcinoma (the so-called Correa pathway).
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