ArticleSocial cognitive and affective neuroscience2014
Variation in oxytocin receptor gene (OXTR) polymorphisms is associated with emotional and behavioral reactions to betrayal.
Article in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Genetic modulation of oxytocin sensitivity: a pharmacogenetic approach.Translational psychiatry · 2015Trial
- Genetic Predisposition and Infidelity: From Molecular Variation to Relationship Behavior-A Narrative Review.International journal of molecular sciences · 2026Review
- OXTR polymorphisms associated with severity and treatment responses of schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- The promiscuity of the oxytocin-vasopressin systems and their involvement in autism spectrum disorder.Handbook of clinical neurology · 2021Review
- Associations between Oxytocin Receptor (OXTR) Genotype and Elementary School Children's Likability, Dis-likability and Friendship among Classroom Peers: A Longitudinal Study.Journal of youth and adolescence · 2018Article
- Polymorphisms of the oxytocin receptor gene and overeating: the intermediary role of endophenotypic risk factors.Nutrition & diabetes · 2017Article
- Signatures of positive selection in the cis-regulatory sequences of the human oxytocin receptor (OXTR) and arginine vasopressin receptor 1a (AVPR1A) genes.BMC evolutionary biology · 2015Article
- Associations between oxytocin receptor genotypes and social cognitive performance in individuals with schizophrenia.Schizophrenia research · 2014Article
- Social cognition, face processing, and oxytocin receptor single nucleotide polymorphisms in typically developing children.Developmental cognitive neuroscience · 2014Article
- Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Navigating the complex path between the oxytocin receptor gene (OXTR) and cooperation: an endophenotype approach.Frontiers in human neuroscience · 2013Review
- A paradoxical association of an oxytocin receptor gene polymorphism: early-life adversity and vulnerability to depression.Frontiers in neuroscience · 2013Article
- Oxytocin and social salience: a call for gene-environment interaction research.Frontiers in neuroscience · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Variations in the gene that encodes the oxytocin receptor (OXTR) have been associated with many aspects of social cognition as well as several prosocial behaviors. However, potential associations of OXTR variants with reactions to betrayals of trust while cooperating for mutual benefit have not yet been explored. We examined how variations in 10 single-nucleotide polymorphisms on OXTR were associated with behavior and emotional reactions after a betrayal of trust in an iterated Prisoner's Dilemma Game. After correction for multiple testing, one haplotype (C-rs9840864, T-rs2268494) was significantly associated with faster retaliation post-betrayal-an association that appeared to be due to this haplotype's intermediate effect of exacerbating people's anger after they had been betrayed. Furthermore, a second haplotype (A-rs237887, C-rs2268490) was associated with higher levels of post-betrayal satisfaction, and a third haplotype (G-rs237887, C-rs2268490) was associated with lower levels of post-betrayal satisfaction.
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