ArticleCerebral cortex (New York, N.Y. : 1991)2014
Motor cortex broadly engages excitatory and inhibitory neurons in somatosensory barrel cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
67 citing papers in PubMed, 114 citations in OpenAlex.
- Circuit Organization of the Forelimb-Related M2-to-M1 Corticocortical Pathway in the Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Circuit organization of the forelimb-related M2-to-M1 corticocortical pathway in the mouse.bioRxiv : the preprint server for biology · 2026Article
- Somatosensory control of thalamic relay neurons is regulated by two distinct layer 6 feedback systems.iScience · 2026Article
- Article
- Interactions between motor cortical forelimb regions and their influence on muscles reorganize across behaviors.Nature communications · 2025Article
- Somatostatin neurons detect stimulus-reward contingencies to reduce neocortical inhibition during learning.Cell reports · 2025Article
- Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouse's hand.eLife · 2025Article
- Touch-evoked traveling waves establish a translaminar spacetime code.Science advances · 2025Article
- Potential impacts of acupuncture on motor function recovery after ischemic stroke: insights from basic and clinical studies.Frontiers in cellular neuroscience · 2025Review
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- Motor Control of Distinct Layer 6 Corticothalamic Feedback Circuits.bioRxiv : the preprint server for biology · 2024Article
- Article
- Functional dynamics and selectivity of two parallel corticocortical pathways from motor cortex to layer 5 circuits in somatosensory cortex.bioRxiv : the preprint server for biology · 2024Article
- Neurocircuitry basis of motor cortex-related analgesia as an emerging approach for chronic pain management.Nature. Mental health · 2024Article
- Interareal Synaptic Inputs Underlying Whisking-Related Activity in the Primary Somatosensory Barrel Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cerebellar Purkinje cell firing promotes conscious recovery from anesthesia state through coordinating neuronal communications with motor cortex.Theranostics · 2024Article
- Sparse and distributed cortical populations mediate sensorimotor integration.bioRxiv : the preprint server for biology · 2023Article
- Comparing electrical stimulation functional mapping with subdural electrodes and stereoelectroencephalography.Epilepsia · 2023Article
- Somatostatin-expressing interneurons modulate neocortical network through GABAb receptors in a synapse-specific manner.Scientific reports · 2023Article
- Motor cortex gates distractor stimulus encoding in sensory cortex.Nature communications · 2023Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Anatomical studies have shown that primary somatosensory (S1) and primary motor (M1) cortices are reciprocally connected. The M1 to S1 projection is thought to represent a modulatory signal that conveys motor-related information to S1. Here, we investigated M1 synaptic inputs to S1 by injecting an AAV virus containing channelrhodopsin-2 and a fluorescent tag into M1. Consistent with previous results, we found labeling of M1 axons within S1 that was most robust in the deep layers and in L1. Labeling was sparse in L4 and was concentrated in the interbarrel septa, largely avoiding barrel centers. In S1, we recorded in vitro from regular-spiking excitatory neurons and fast-spiking and somatostatin-expressing inhibitory interneurons. All 3 cell types had a high probability of receiving direct excitatory M1 input. Both excitatory and inhibitory cells within L4 were the least likely to receive such input from M1. Disynaptic inhibition was observed frequently, indicating that M1 recruits substantial inhibition within S1. Additionally, a subpopulation of L6 regular-spiking excitatory neurons received exceptionally strong M1 input. Overall, our results suggest that activation of M1 evokes within S1 a bombardment of excitatory and inhibitory synaptic activity that could contribute in a layer-specific manner to state-dependent changes in S1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.