ArticleJournal of experimental botany2013
Transgenic wheat expressing Thinopyrum intermedium MYB transcription factor TiMYB2R-1 shows enhanced resistance to the take-all disease.
Article in Journal of experimental botany, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 96 citations in OpenAlex.
- Physiological and biochemical markers associated with root lignification and micronutrient uptake in wheat genotypes with contrasting resistance to Gaeumannomyces tritici.Scientific reports · 2026Article
- Silencing of the Mycorrhiza-Inducible Phosphate TransporterPlants (Basel, Switzerland) · 2026Article
- The PcMYB44-mediated miR397-PcLACs module regulates defence-induced lignification in pear resistance to fungal disease.Molecular plant pathology · 2023Article
- Review
- Article
- Genome-Wide Characterization and Analysis of R2R3-MYB Genes Related to Fruit Ripening and Stress Response in Banana (Plants (Basel, Switzerland) · 2022Article
- A R2R3 MYB Transcription Factor,International journal of molecular sciences · 2022Article
- MYB Transcription Factors Becoming Mainstream in Plant Roots.International journal of molecular sciences · 2022Review
- Isolation and Functional Characterization of a Green-Tissue Promoter in Japonica Rice (Biology · 2022Article
- Important wheat diseases in the US and their management in the 21st century.Frontiers in plant science · 2022Review
- The Transcription Factor MYB37 Positively Regulates Photosynthetic Inhibition and Oxidative Damage in Arabidopsis Leaves Under Salt Stress.Frontiers in plant science · 2022Article
- PlantsFrontiers in plant science · 2022Review
- Genome-Wide Association Mapping and Gene Expression Analysis Reveal the Negative Role of OsMYB21 in Regulating Bacterial Blight Resistance in Rice.Rice (New York, N.Y.) · 2021Article
- TaMYB29: A Novel R2R3-MYB Transcription Factor Involved in Wheat Defense Against Stripe Rust.Frontiers in plant science · 2021Article
- Biocontrol of Two Bacterial Inoculant Strains and Their Effects on the Rhizosphere Microbial Community of Field-Grown Wheat.BioMed research international · 2021Article
- Commonly and Specifically Activated Defense Responses in Maize Disease Lesion Mimic Mutants Revealed by Integrated Transcriptomics and Metabolomics Analysis.Frontiers in plant science · 2021Article
- Complex relationship between DNA methylation and gene expression due to Lr28 in wheat-leaf rust pathosystem.Molecular biology reports · 2020Article
- A predicted protein functional network aids in novel gene mining for characteristic secondary metabolites in tea plantJournal of biosciences · 2020Article
- The Highly Conserved Barley Powdery Mildew EffectorInternational journal of molecular sciences · 2019Article
- Integrative Analysis of the WheatCells · 2019Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The disease take-all, caused by the fungus Gaeumannomyces graminis, is one of the most destructive root diseases of wheat worldwide. Breeding resistant cultivars is an effective way to protect wheat from take-all. However, little progress has been made in improving the disease resistance level in commercial wheat cultivars. MYB transcription factors play important roles in plant responses to environmental stresses. In this study, an R2R3-MYB gene in Thinopyrum intermedium, TiMYB2R-1, was cloned and characterized. The gene sequence includes two exons and an intron. The expression of TiMYB2R-1 was significantly induced following G. graminis infection. An in vitro DNA binding assay proved that TiMYB2R-1 protein could bind to the MYB-binding site cis-element ACI. Subcellular localization assays revealed that TiMYB2R-1 was localized in the nucleus. TiMYB2R-1 transgenic wheat plants were generated, characterized molecularly, and evaluated for take-all resistance. PCR and Southern blot analyses confirmed that TiMYB2R-1 was integrated into the genomes of three independent transgenic wheat lines by distinct patterns and the transgene was heritable. Reverse transcription-PCR and western blot analyses revealed that TiMYB2R-1 was highly expressed in the transgenic wheat lines. Based on disease response assessments for three successive generations, the significantly enhanced resistance to take-all was observed in the three TiMYB2R-1-overexpressing transgenic wheat lines. Furthermore, the transcript levels of at least six wheat defence-related genes were significantly elevated in the TiMYB2R-1 transgenic wheat lines. These results suggest that engineering and overexpression of TiMYB2R-1 may be used for improving take-all resistance of wheat and other cereal crops.
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